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Article Abstract
Previous studies on estimating human exposure to PCBs often employed daily or hourly fixed intakes, failing to consider the irregularity of PCBs accumulation under a real consumption scenario. Therefore, this study aimed at simulating actual consumer behavior, estimating the specific dates and quantities of PCB-153 intake, and combining this approach with a pharmacokinetic model to estimate the human exposure to PCB-153 through Tuna consumption. A physiologically based pharmacokinetic (PBPK) model was used to predict the accumulation of PCB-153 in six tissue compartments of a hypothetical woman for a period of 10 years. The simulated intake amount was 16313 ± 3797 ng/year, resulting in accumulated PCB-153 concentration in whole blood of 460 ± 12.6 ng/L after 10 years, which aligns closely with the human biomonitoring measurement results. This study provides a promising approach to understand and evaluate the exposure and accumulation of food-source pollutants in the human body, as well as to inform public health policy.
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| http://dx.doi.org/10.2131/jts.50.493 | DOI Listing |
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