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http://dx.doi.org/10.24869/psyd.2025.170 | DOI Listing |
J Clin Invest
September 2025
Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Boston, United States of America.
B-lymphocytes play major adaptive immune roles, producing antibody and driving T-cell responses. However, how immunometabolism networks support B-cell activation and differentiation in response to distinct receptor stimuli remains incompletely understood. To gain insights, we systematically investigated acute primary human B-cell transcriptional, translational and metabolomic responses to B-cell receptor (BCR), Toll-like receptor 9 (TLR9), CD40-ligand (CD40L), interleukin-4 (IL4) or combinations thereof.
View Article and Find Full Text PDFPlant Biotechnol J
September 2025
National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan, China.
Abscisic acid (ABA) and calcium respectively work as crucial plant hormones and second signalling molecules in the regulation of fruit development and quality formation, including the sugar content and flavour quality. However, the regulatory mechanisms of fruit sugar accumulation arising from the interaction between ABA and calcium have not yet been fully elucidated. Here, we show that the application of ABA or calcium enhances sugar accumulation in sweet orange (Citrus sinensis) fruit, accompanied by upregulation of the expression level of tonoplast sugar transporter 2 (CsTST2), which mediates the transport of sugars into the vacuole.
View Article and Find Full Text PDFJCI Insight
September 2025
Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute, and.
Steroid-refractory gut acute graft-versus-host disease (SR-Gut-aGVHD) is the major cause of nonrelapse death after allogeneic hematopoietic cell transplantation. High numbers of donor-type IL-22+ T cells, IL-22-dependent dysbiosis, and loss of antiinflammatory CX3CR1hi mononuclear phagocytes (MNPs) play critical roles in SR-Gut-aGVHD pathogenesis. CEACAM1 on intestinal epithelial cells (IECs) is proposed to regulate bacterial translocation and subsequent immune responses in the intestine.
View Article and Find Full Text PDFPlant Biotechnol J
September 2025
College of Agronomy, Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, Henan Agricultural University, Zhengzhou, China.
The magnetic field is a continuously present environmental factor. It has been found that many species, including plants, can sense and utilise it. However, the effects of the magnetic field on plants and its potential utilisation, especially in crops, have been little explored.
View Article and Find Full Text PDFFood Res Int
November 2025
School of Life Sciences, Mianyang Normal University, Mianyang City, Sichuan Province 621000, China. Electronic address:
As a dual-purpose medicinal and edible plant, Ocimum species offer significant pharmacological potential through their alkaloid metabolites. This study comprehensively analyzed alkaloid profiles in 10 Ocimum accessions using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), integrated with network pharmacology, molecular docking, and transcriptome sequencing to elucidate key pharmacological targets, therapeutic potentials, and biosynthetic pathways. We identified 191 alkaloids categorized into eight classes, with phenolamine and plumerane alkaloids predominating.
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