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This study examines the intricate task of predicting construction duration for drill-and-blast tunnels utilizing machine learning (ML) techniques. First, a comprehensive dataset (500 data points) encompassing 20 diverse parameters was compiled by constructing eight tunnels. After meticulous analysis, 17 of the 20 parameters were identified as crucial for training the algorithms. The overbreak and tunnel cross-section parameters were found to exert a significant influence on the tunnel construction duration. To enhance the predictive accuracy of the ML models, an intensive hyperparameter tuning process was conducted. The findings underscored the effectiveness of the Gaussian process regression model in capturing complex and nonlinear relationships, achieving an average R-squared of 0.89. Additionally, an ML-based graphical user interface (GUI) was developed to facilitate real‒time estimation of tunnel construction duration. This GUI not only enables initial predictions but also allows for dynamic updates throughout the construction phase, enhancing its practical utility.
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http://dx.doi.org/10.1038/s41598-025-17455-7 | DOI Listing |
Brain Behav
September 2025
Department of Dermatology, Yulin First Hospital, Yulin, Shaanxi Province, China.
Background: Psoriasis is linked with an elevated risk of anxiety disorders, and there may be a temporal relationship between the two. However, the association between anxiety status and its duration with psoriasis is unclear.
Objectives: The present work aimed to figure out the association between anxiety and the risk of psoriasis.
Background: During left bundle branch area pacing (LBBAP), several markers of electrical synchrony, (V6 R-wave peak time (RWPT), aVL-RWPT, and the V6-V1 interpeak interval), are commonly used to assess left bundle branch (LBB) capture. Nevertheless, the relationship between these electrocardiographic (ECG) measurements and mechanical synchrony remains poorly understood.
Objective: We aimed to analyze the association between electrical parameters from the paced QRS complex and mechanical performance assessed through 2D strain and myocardial work (MW) indices, following LBBAP implantation.
J Am Soc Echocardiogr
September 2025
Department of Cardiology and Vascular Medicine, Universitas Indonesia, Indonesia. Electronic address:
Nearly 30% of patients with cardiac resynchronization therapy (CRT) are non- responders. Speckle tracking echocardiography (STE) parameters are able to evaluate electromechanical dyssynchrony that could improve outcomes. We aim to examine the association between various STE parameters with CRT response and clinical outcomes in heart failure patients.
View Article and Find Full Text PDFPLoS One
September 2025
NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and Institute of Ophthalmology University College London, London, United Kingdom.
Objectives: To describe the research principles and cohort characteristics of the multi-disciplinary Project HERCULES, an innovative model of safe high-volume outpatient eye-care service for patients with stable chronic eye diseases. Results and analyses of the workstreams within Project HERCULES will be reported elsewhere. The rationale was to improve eye-care capacity in the National Health Service (NHS) in England through the creation of technician-delivered monitoring in a large retail-unit in a London shopping-centre, with remote asynchronous review of results by clinicians (named Eye-Testing and Review through Asynchronous Clinic (Eye-TRAC)).
View Article and Find Full Text PDFHum Reprod Open
August 2025
Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Study Question: Do social determinants of health (SDoH) influence the age at menopause among women?
Summary Answer: In our study, adverse SDoH, particularly family low income-to-poverty ratio (PIR), low education level, and the marital status of being widowed, are associated with earlier age at menopause.
What Is Known Already: Some prior studies have considered certain SDoH variables (such as educational attainment and marital status) as potential factors influencing age at menopause, but systematic evidence clearly defining the relationship between multidimensional SDoH and menopausal age remains lacking.
Study Design Size Duration: This cross-sectional analysis included 6083 naturally menopausal women from 10 cycles (1999-2018) of the United States National Health and Nutrition Examination Survey (NHANES) and excluded cases of surgical menopause.