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Article Abstract
Objective: To investigate the distribution characteristics of methicillin-resistant (MRSA) infection in people living with HIV (PLWH), to analyse the risk factors of MRSA colonisation in the nasopharynx of PLWH, and to provide a scientific basis for the prevention of hospital-acquired MRSA infection in PLWH.
Methods: This study used a cross-sectional research design to analyse 1,100 PLWH attending the AIDS outpatient clinic of the People's Hospital of Dongyang City, Zhejiang Province, from January 2022 to December 2024. Nasal swabs were collected with informed consent, and epidemiological information was collected via questionnaire. Standard microbiological methods were used for isolation and identification of strains, with drug susceptibility testing performed using the K-B paper diffusion method. PCR was used to detect virulence genes and Statistical analysis was conducted using Stata13.0 software.
Results: Of the 1,100 PLWH enrolled, 275 (25%) were colonized with , of which 98 (35.63%) carried MRSA and 177 (64.37%) carried MSSA. The mean age of MRSA carriers (51.32 ± 15.87 years) was significantly higher than that of MSSA carriers (44.26 ± 18.93 years) ( < 0.001). MRSA had a high prevalence of resistance to a wide range of antibiotics, including penicillin, oxacillin, amoxicillin and amoxicillin/clavulanic acid. The virulence gene was detected more frequently in MSSA than in MRSA. In PLWH, respiratory infections in the previous 12 months, lack of antiretroviral therapy and heterosexual transmission were associated with a higher risk of nasal carriage of MRSA.
Conclusion: The study provides valuable insights into the characteristics and distribution of MRSA and MSSA cases, as well as the factors influencing the nasal carriage of , particularly MRSA, in PLWH. These findings can guide clinical practice and infection control measures to reduce the incidence and spread of MRSA infections in high-risk populations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380835 | PMC |
| http://dx.doi.org/10.3389/fmicb.2025.1634460 | DOI Listing |
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