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http://dx.doi.org/10.1161/JAHA.125.044210 | DOI Listing |
Turk J Pediatr
September 2025
Department of Cardiorespiratory Physiotherapy and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Türkiye.
Background: Vascular changes are observed in children with cystic fibrosis (cwCF), and gender-specific differences may impact arterial stiffness. We aimed to compare arterial stiffness and clinical parameters based on gender in cwCF and to determine the factors affecting arterial stiffness in cwCF.
Methods: Fifty-eight cwCF were included.
PLoS One
September 2025
Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Objective: This study investigates the mechanisms behind exercise capacity in adults with type 2 diabetes mellitus (T2DM), focusing on central and peripheral components, as described by the Fick equation.
Methods: A cross-sectional study of 141 adults with T2DM was conducted, using cardiopulmonary exercise testing, near-infrared spectroscopy (NIRS) and exercise echocardiography. Participants with sufficient-quality NIRS data were stratified into tertiles based on percentage predicted VO₂peak.
JACC Cardiovasc Imaging
September 2025
Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium. Electronic address:
Background: Atrial functional mitral regurgitation (AFMR) is prevalent among patients with heart failure with preserved ejection fraction (HFpEF) and associated with adverse outcome, yet this bidirectional association remains underexplored.
Objectives: The purpose of this study was to elucidate the pathophysiological and prognostic significance of AFMR in HFpEF, both at rest and during exercise.
Methods: In this multicenter cohort study, consecutive patients with HFpEF underwent cardiopulmonary exercise testing with echocardiography, with a particular focus on mitral regurgitation (MR) severity assessment in rest and during exercise.
J Cardiovasc Pharmacol
September 2025
Robert M. Berne Cardiovascular Research Center, and Division of Cardiology, University of Virginia, Charlottesville, Virginia, United States.
Cardiorespiratory fitness (CRF) in heart failure (HF) declines with age. Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging and HF. We aimed to determine the changes in CRF before and after treatment with anakinra, recombinant IL-1 receptor antagonist, in patients with HF stratified according to age below and above 60 years in phase II clinical trials.
View Article and Find Full Text PDFInt J Cardiol
September 2025
Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany. Electronic address:
Background: Patients with Fontan circulation are often advised to avoid hypoxic exposure due to presumed cardiopulmonary vulnerability. Low-grade inflammation has also been reported in this population and may be influenced by hypoxia and/or exercise. Based on the potential interaction between hypoxia and submaximal exercise in modulating inflammatory signaling, we hypothesized that this combination could exacerbate subclinical inflammation.
View Article and Find Full Text PDF