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Background: Diabetes mellitus is a complex endocrine condition affecting the periodontal status of an individual. The current study aimed to assess oral health related quality of life (OHRQL), xerostomia severity, and periodontal status in both controlled and uncontrolled Type 2 Diabetes mellitus. (T2DM) METHODS: Eighty patients with type 2 diabetes aged between 35 and 70 were divided equally in Group I: patients with controlled T2DM and Group II: patients with uncontrolled T2DM. Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) parameters were assessed. Additionally, xerostomia severity was determined through questionnaire of 11-point xerostomia inventory and OHRQL through 14-point oral health impact profile. (OHIP-14) RESULTS: The mean HbA1C values differed significantly in the two groups with Group I exhibiting values of 6.97 ± 0.45 gm% and Group II with 9.78 ± 2.31 gm%. The patients in Group II had significantly higher mean PD, CAL, and BOP values in comparisonto Group I. Similar corresponding values were obtained for xerostomia severity and OHIP-14 scores for OHRQL. On comparison between the groups the periodontal status manifested by clinical parameters exhibited more severity while xerostomia severity and OHRQL, was negatively impacted in Group II patients when compared with Group I.
Conclusion: Poor glycaemic control substantially influences periodontal health, xerostomia severity, and oral health-related quality of life. Early periodontal intervention and maintenance of optimal glycaemic control are crucial to improve overall oral and systemic health in diabetic patients.
Trial Registration Number: CTRI/2025/04/086064 Date: 30 April 2025.
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http://dx.doi.org/10.1186/s12903-025-06805-6 | DOI Listing |
J Oral Rehabil
September 2025
Department of Prosthodontics, Dental School, National and Kapodistrian University of Athens, Athens, Greece.
Background: Although oral diseases and frailty can be met earlier in life, there is limited information on their association across the lifespan.
Objectives: To scope for the association of oral factors with physical frailty in Greek community-dwelling adults.
Methods: Participants were over 18 years of age with ≥ 20 natural teeth, ≥ 10 occlusal contacts, and no removable dentures.
Immunol Res
September 2025
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Belisario Domínguez Sección XVI, Avenida Vasco de Quiroga 15, C.P. 14080, Tlalpan, Mexico City, Mexico.
We present six patients with dysautonomia secondary to primary Sjögren's disease (pSjD) and analyze the literature regarding this topic. Case series. Patients were retrospectively recruited from a tertiary center in Mexico from 2001 to 2022 and included if they met 2016 ACR/EULAR criteria for SjD.
View Article and Find Full Text PDFMol Imaging Biol
September 2025
Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Purpose: While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the α-emitting RLT often results in severe salivary gland toxicity, limiting its use. Various strategies to mitigate this side effect have been attempted with limited success. Accordingly, this study introduced a new PSMA-targeting ligand with more favorable binding characteristics than the existing ligands.
View Article and Find Full Text PDFBMC Oral Health
August 2025
Department of Periodontics and Implantology, Ranjeet Deshmukh Dental College and Research Centre, Nagpur, India.
Background: Diabetes mellitus is a complex endocrine condition affecting the periodontal status of an individual. The current study aimed to assess oral health related quality of life (OHRQL), xerostomia severity, and periodontal status in both controlled and uncontrolled Type 2 Diabetes mellitus. (T2DM) METHODS: Eighty patients with type 2 diabetes aged between 35 and 70 were divided equally in Group I: patients with controlled T2DM and Group II: patients with uncontrolled T2DM.
View Article and Find Full Text PDFBiomedicines
August 2025
Department of Dermatovenereology, University Hospital Center Sestre Milosrdnice, 10000 Zagreb, Croatia.
Cutaneous and oral mucosal adverse events (AEs) are among the most common non-hematologic toxicities observed during breast cancer treatment. These complications arise across various therapeutic modalities including chemotherapy, targeted therapy, hormonal therapy, radiotherapy, and immunotherapy. Although often underrecognized compared with systemic side effects, dermatologic and mucosal toxicities can severely impact the patients' quality of life, leading to psychosocial distress, pain, and reduced treatment adherence.
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