Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Establishment and maintenance of specialized CMs in the heart is critical for the proper cardiac structure and function. Conversely, loss or gain of their identities is associated with various heart diseases such as cardiac arrythmia and cardiomyopathy. CM identity is established during early heart development and continues to be maintained under normal physiological condition, and this is predominantly accomplished by gene regulation. Our understanding of potential genetic, epigenetic or posttranscriptional programs that regulate CM identity (e.g., atrial or ventricular CM identity) is still quite limited. To this end, we summarize current understandings on atrial and ventricular CM identity regulations and discuss potential future research directions to unveil the underlying regulatory mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.yjmcc.2025.08.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The CONDUCT-AF trial: Rationale and design of a prospective, randomized, multicentre study comparing conduction system and biventricular pacing in patients undergoing atrioventricular node ablation for heart failure with atrial fibrillation.
Eur J Heart Fail
September 2025
Cardiology Department, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Aims: There is a lack of data from randomized clinical trials comparing treatment outcomes between conduction system pacing (CSP) modalities and biventricular pacing (BVP) in symptomatic patients with refractory atrial fibrillation (AF) scheduled for atrioventricular node ablation (AVNA). The CONDUCT-AF investigates whether CSP is non-inferior to BVP in improving left ventricular ejection fraction (LVEF) and clinical outcomes in heart failure (HF) patients with symptomatic AF undergoing AVNA.
Methods: This study is an investigator-initiated, prospective, randomized, multicentre clinical trial conducted across 10 European centres, enrolling 82 patients with symptomatic AF, HF with reduced LVEF, and narrow QRS.
The Relationship Between the CHA2DS2-VASc Score and Lesion Complexity and Long-Term Outcomes in Peripheral Arterial Disease.
Turk Kardiyol Dern Ars
September 2025
Department of Cardiology, Dicle University School of Medicine, Diyarbakır, Turkiye.
Objective: Originally designed to evaluate stroke risk in individuals with atrial fibrillation unrelated to valvular disease, the CHA2DS2-VASc score (Congestive heart failure, Hypertension, Age ≥ 75 years, Diabetes mellitus, prior Stroke/transient ischemic attack/systemic embolism, Vascular disease, Age 65-74 years, and Sex category - female) is now additionally utilized for the prognostic evaluation of cardiovascular diseases. This study aimed to evaluate the predictive role of the CHA2DS2-VASc score for lesion severity and long-term survival outcomes in individuals with peripheral artery disease (PAD).
Method: This retrospective analysis included 784 patients diagnosed with PAD via computed tomography (CT) angiography, consecutively enrolled from two medical centers.
Asymptomatic Apical Hypertrophic Cardiomyopathy Uncovered During Routine Preoperative Evaluation.
Cureus
August 2025
Medicine/Cardiology, Madigan Army Medical Center, Tacoma, USA.
Apical hypertrophic cardiomyopathy (ApHCM) is an uncommon, nonobstructive form of hypertrophic cardiomyopathy (HCM) that is associated with an increased risk of ventricular aneurysms, atrial fibrillation, heart failure, and cardiac death. In this case report, a 63-year-old male patient was found to have deeply negative T waves on electrocardiogram (EKG) during a routine preoperative evaluation in an outpatient internal medicine clinic. Imaging with echocardiography and cardiac magnetic resonance confirmed the diagnosis of ApHCM.
View Article and Find Full Text PDFPostoperative Atrial Fibrillation Following Anatomic Lung Resection: A Case Report and Narrative Review of Contemporary Pharmacologic Management.
Cureus
August 2025
Department of Surgery, University of Minnesota, Minneapolis, USA.
Postoperative atrial fibrillation (POAF) is a common complication following anatomic lung resection, contributing to increased morbidity and mortality, prolonged hospital stays, and higher healthcare costs. Despite its frequency, there remains limited consensus on optimal pharmacologic management in this population, particularly in the context of balancing efficacy with the unique risks associated with thoracic surgery. This report aims to draw attention to the clinical significance of POAF in thoracic surgery, particularly following pulmonary resections, by presenting a representative case and contextualizing it through a focused review of current literature and consensus guidelines.
View Article and Find Full Text PDFRelationship between carotid-femoral pulse wave velocity and decreased left ventricular diastolic function in patient with coronary heart disease: a cross-sectional study.
Front Cardiovasc Med
August 2025
Department of Cardiovascular Medicine, Fengxian Central Hospital, Shanghai, China.
Background: Arterial compliance is an independent predictor of diastolic dysfunction. Invasive catheterization can accurately reflect diastolic function. However, studies on the invasive assessment of diastolic function are currently limited.
View Article and Find Full Text PDF