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In this paper, we introduce a novel framework for creating multimodal interactive digital twin characters, from dialogue videos of TV shows. Specifically, these digital twin characters are capable of responding to user inputs with harmonious textual, vocal, and visual content. They not only replicate the external characteristics, such as appearance and tone, but also capture internal attributes, including personality and habitual behaviors. To support this ambitious task, we collect the Multimodal Character-Centric Conversation Dataset, named MCCCD, which includes character-specific and high-quality multimodal dialogue data with detailed annotations, featuring 6.8 k utterances and 4.6 hours of audio/video per character. Notably, the MCCCD dataset is approximately ten times larger than existing datasets in terms of per-character data volume, facilitating the detailed modeling of complex character-centric traits. Further, we propose a baseline framework to create digital twin characters, consists of dialogue generation through large language models, voice generation via speech synthesis models, and visual representation with 3D talking head models. Experimental results demonstrate that our approach significantly outperforms existing methods in generating consistent and character-specific responses, setting a new benchmark for digital character creation. Our collected dataset and proposed baseline have paved the way for the creation of highly interactive and natural digital avatars, opening the door to extensive and practical applications of digital humans. The full dataset and data collection code are publicly available.
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http://dx.doi.org/10.1109/TPAMI.2025.3603653 | DOI Listing |
Cereb Cortex
August 2025
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Marseille 13005, France.
Over three decades, statistical parametric mapping has transformed neuroimaging from descriptive mapping to causal inference, placing generative models at the core of causal explanations for brain function. It inspired to a large degree The Virtual Brain, which builds subject-specific digital twins from multimodal data, enabling brain simulations and exploration. Both frameworks converge at parameter estimation, where model and data meet, providing the mathematical manifestation of cause-effect in pathophysiology.
View Article and Find Full Text PDFComput Struct Biotechnol J
August 2025
Institut de Recherche en Cancérologie de Montpellier (IRCM), Équipe Labellisée Ligue Contre le Cancer, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Digital twins (DTs) are emerging tools for simulating and optimizing therapeutic protocols in personalized nuclear medicine. In this paper, we present a modular pipeline for constructing patient-specific DTs aimed at assessing and improving dosimetry protocols in PRRT such as therapy. The pipeline integrates three components: (i) an anatomical DT, generated by registering patient CT scans with an anthropomorphic model; (ii) a functional DT, based on a physiologically-based pharmacokinetic (PBPK) model created in SimBiology; and (iii) a virtual clinical trial module using GATE to simulate particle transport, image simulation, and absorbed dose distribution.
View Article and Find Full Text PDFACS Nano
September 2025
Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, Zhejiang 315200, P. R. China.
Ni-Fe (oxy)hydroxides are among the most active oxygen evolution reaction (OER) catalysts in alkaline media. However, achieving precise control over local asymmetric Fe-O-Ni active sites in Ni-Fe oxyhydroxides for key oxygenated intermediates' adsorption steric configuration regulation of the OER is still challenging. Herein, we report a two-step dealloying strategy to fabricate asymmetric Fe-O-Ni pair sites in the shell of NiOOH@FeOOH/NiOOH heterostructures from NiFe Prussian blue analogue (PBA) nanocubes, involving anion exchange and structure reconstruction.
View Article and Find Full Text PDFCompr Rev Food Sci Food Saf
September 2025
Department of Life Science (Food Science and Technology Division), GITAM University, Visakhapatnam, Andhra Pradesh, India.
Drying is a critical unit operation in food processing, essential for extending shelf life, ensuring microbial safety, and preserving the nutritional and sensory attributes of food products. However, conventional convective drying techniques are often energy-intensive and lead to undesirable changes such as texture degradation, loss of bioactive compounds, and reduced product quality, thereby raising concerns regarding their sustainability and efficiency. In response, recent advancements have focused on the development of innovative drying technologies that offer energy-efficient, rapid, and quality-preserving alternatives.
View Article and Find Full Text PDFInt J Surg
September 2025
First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, China.