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Article Abstract
A comparative analysis of testicular tumors in dogs and humans highlights notable similarities in cancer behavior, particularly regarding environmental influences. The ubiquitous distribution of endocrine disruptors in industrialized countries and their effects are strongly linked to the development of testicular cancers. This study examined 221 and 174 cases of testicular tumor in dogs and humans, respectively, from the Campania Animal Cancer Registry and the database of the National Cancer Institute "Fondazione G. Pascale-IRCCS", between 2020 and 2023. These data were integrated with environmental data from the Ministry of Environment and Energy Security website and the Campania Regional Agency for Environmental Protection (ARPAC). The areas with the highest frequency of testicular tumors in both species were the municipalities of Napoli, Salerno, and Caserta, and their corresponding provinces. The same locations experienced severe contamination of soil and water by environmental pollutants, probably correlated to testicular tumors. Although the molecular mechanisms are not yet fully understood, our data suggest a strong link between the frequency of testicular tumors in humans and dogs and high concentrations of environmental pollutants in the reported locations. These findings emphasize the value of dogs as a potential animal model for studying human health and the effect of environmental factors on cancer development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12390463 | PMC |
| http://dx.doi.org/10.3390/vetsci12080695 | DOI Listing |
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