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We reviewed those diagnosed pre- and postnatally with interrupted inferior caval vein (IICV), emphasizing the computed tomographic (CT) findings in those without complex cardiac malformations. We identified cases of IIVC diagnosed between January 2013 and December 2024. We defined non-complex cardiac malformations as secundum atrial communications with or without catheter intervention or surgery, mild semilunar valve stenosis, or a patent ductus arteriosus with or without catheter intervention or surgery. We identified 51 cases of IIVC, of which 49 had prenatal care. Of the 49 with prenatal care, 46 (94%) were diagnosed prenatally. Of the 46 prenatally diagnosed, 5 underwent fetal demise, 1 elective termination, and 40 were live born. Of the 45 live born (5 non-prenatally and 40 prenatally diagnosed), 31 (69%) had no complex cardiac malformation. Of these 31, 10 (32%) underwent CT scanning. In our experience, we noted a high prenatal detection rate for IICV, with most having no complex cardiac malformations. Further, CT scanning in a subset of patients without complex cardiac malformations demonstrated elements of left-isomeric situs, including left-atrial appendage isomerism.
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http://dx.doi.org/10.1007/s00246-025-04004-2 | DOI Listing |
Cardiol Young
September 2025
Congenital Valve Procedural Planning Program, Division of Pediatric Cardiac Surgery, Cleveland Clinic Children's, and Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Background: Congenital aortic valvar disease represents a heterogeneous population with suboptimal surgical repair or replacement outcomes. We assess our approach and short-term outcomes in this population using cardiac CT evaluation for personalised surgical planning and execution.
Methods: We assessed patients who underwent aortic valvar surgery from February 2022 to August 2024.
Ann Palliat Med
September 2025
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Radical esophagectomy remains the cornerstone of curative treatment for esophageal cancer, but is frequently complicated by postoperative events, most notably anastomotic leakage. Anastomotic leakage, occurring in up to 30% of cases, is multifactorial in origin and significantly increases morbidity and mortality. This review aims to summarize current management strategies, highlight emerging therapies, and identify persistent clinical challenges related to this complication.
View Article and Find Full Text PDFStem Cell Rev Rep
September 2025
Department of Medical Genetics and Prenatal Diagnostics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The emergence of organoid models has significantly bridged the gap between traditional cell cultures/animal models and authentic human disease states, particularly for genetic disorders, where their inherent genetic fidelity enables more biologically relevant research directions and enhances translational validity. This review systematically analyzes established organoid models of genetic diseases across organs (e.g.
View Article and Find Full Text PDFPediatr Cardiol
September 2025
Division of Cardiology, Children's National Hospital, 111 Michigan Ave, Washington, DC, 20010, USA.
Patients with acquired and congenital heart disease (CHD) are at higher risk of hospitalization. Despite quality improvement (QI) initiatives, many patients experience readmission soon after discharge. We aimed to identify risk factors for 30-day readmission and hypothesized that direct discharge from the cardiac intensive care unit (CICU) is associated with an increased readmission rate.
View Article and Find Full Text PDFMol Syst Biol
September 2025
Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Vascular sites have distinct susceptibility to atherosclerosis and aneurysm, yet the epigenomic and transcriptomic underpinning of vascular site-specific disease risk is largely unknown. Here, we performed single-cell chromatin accessibility (scATACseq) and gene expression profiling (scRNAseq) of mouse vascular tissue from three vascular sites. Through interrogation of epigenomic enhancers and gene regulatory networks, we discovered key regulatory enhancers to not only be cell type, but vascular site-specific.
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