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http://dx.doi.org/10.1016/j.jacbts.2025.04.016 | DOI Listing |
JACC Basic Transl Sci
August 2025
Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy; Interdepartmental Center of Research on Hypertension and Related Conditions (CIRIAPA), Federico II University, Naples, Italy. Electronic address:
Ecotoxicol Environ Saf
August 2025
State Key Laboratory of Agricultural Microbiology Core Facility, Wuhan, Hubei 430070, China; National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei 430070, China; Key Laboratory of Prevention & Control for African Swine Fever and Other Major
8:2 fluorotelomer alcohol (8:2 FTOH), a persistent environmental pollutant, raises concerns due to its potential health risks. With increasing cancer cases and doxorubicin (DOX) chemotherapy use, PFAS-exposed patients face heightened cardiovascular disease (CVD) and drug resistance risks. However, the mechanisms underlying 8:2 FTOH's impact on DOX-induced cardiotoxicity and resistance remain unclear.
View Article and Find Full Text PDFNanoscale
August 2025
Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
The growing threat of antimicrobial resistance and tuberculosis (TB) necessitates innovative therapeutics capable of modulating both infection and host immune responses. In this study, we report the dual anti-tubercular and anti-inflammatory activity of oxygen-functionalized TiCO MXene, a two-dimensional nanomaterial synthesized selective HF etching of TiAlC followed by ethanol-assisted delamination. Structural characterization by XRD and Raman spectroscopy confirmed successful conversion to the MXene phase, with an increased interlayer spacing of 9.
View Article and Find Full Text PDFDiscov Nano
July 2025
Department of Pharmaceutics and Pharmaceutical Technology, Kampala International University, Western Campus, P.O. Box 71, Ishaka, Bushenyi, Uganda.
Triple-negative breast cancer (TNBC) is a prevalent and aggressive subtype of breast cancer, accounting for approximately 10-15% of all cases. Its lack of hormone receptors and poor clinical prognosis make targeted therapy particularly challenging, leaving chemotherapy as the mainstay treatment. However, conventional chemotherapy is associated with significant limitations, including cardiotoxicity and inadequate tumor cell specificity.
View Article and Find Full Text PDFSci Rep
July 2025
Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Leishmaniasis is one of the infectious diseases caused by protozoa and is considered the second most significant parasitic disease after malaria. In this research, thiosemicarbazone Schiff base derivatives were synthesized via a one-pot, two-step, three-component reaction. Then, the effectiveness of the compounds against the two forms of Leishmania major and Leishmania tropica called amastigote and promastigote, was tested.
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