Anthropometry and the Risk of Breast Cancer in Moroccan Women: A Large Multicentric Case-Control Study.

Although evidence suggests adiposity as a modifiable risk factor for postmenopausal breast cancer (BC), its association with premenopausal BC remains uncertain. This potential differential relationship for menopausal status has been insufficiently investigated in the Moroccan population due to limited data. This study aims to assess the relationship between various indicators of adiposity and the risk of BC among Moroccan women by menopausal status. A multicenter case-control study was conducted in Morocco between December 2019 and August 2023, including 1400 incident BC cases and 1400 matched controls. Detailed measures of adiposity and self-reported measures from different life stages were collected. Unconditional logistic regression analyses were conducted to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between body size indicators and the risk of BC, adjusting for a range of known risk factors for BC. Higher waist circumference (WC) and hip circumference (HC) were associated with an increased risk of BC in both pre- (-trend < 0.001 for both WC and HC) and post-menopausal women (-trend < 0.001 for WC, 0.002 for HC). Current body mass index (BMI) ≥30 kg/m increased the risk of postmenopausal BC (-trend = 0.012). Among postmenopausal women, higher weight at age 20 was positively associated with BC risk (-trend < 0.001), while, weight at age 30 was significantly associated with increased BC risk in both pre- (-trend = 0.008) and post-menopausal women (-trend = 0.028). Interestingly, weight gain since age 20 was inversely associated with BC risk in postmenopausal women in the adjusted model (-trend = 0.006). Young-adult BMI observed a significant increased trend with BC risk in both pre- (-trend = 0.008) and post-menopausal women (-trend < 0.001). In premenopausal women, larger body shape during childhood and early adulthood was positively associated with BC risk (-trend = 0.01 and = 0.011, respectively). In postmenopausal women, larger childhood and adolescent body silhouettes were also associated with increased BC risk (-trend = 0.045 and 0.047, respectively). These results suggest that anthropometric factors may have different associations with pre- and post-menopausal BC among Moroccan women. This underscores the importance of conducting large prospective studies to better understand these findings and explore their links to different molecular subtypes of BC.