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Nexplanon is a subdermal contraceptive implant that is generally well tolerated; however, rare complications can occur. Although typical adverse events include localized pain and nerve irritation along specific dermatomes, diffuse neuropathic symptoms are uncommon. This case report suggests that subclinical edema-induced nerve compression, often accompanied by an inflammatory response, may contribute to such atypical presentations.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377928 | PMC |
http://dx.doi.org/10.7759/cureus.88826 | DOI Listing |
Medicine (Baltimore)
September 2025
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Background: Despite a surge in neuropathic pain (NP) biomarker research over the past 2 decades, the translation of discoveries into clinical practice remains slow. To understand this translational gap, we conducted a comprehensive bibliometric analysis to map the field's evolution, intellectual structure, and strategic challenges.
Methods: We conducted a bibliometric analysis of NP biomarker-related publications from 2004 to 2024 using the Web of Science Core Collection (WoSCC) database.
Semin Vasc Surg
September 2025
Division of Vascular and Endovascular Surgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY; Comprehensive Wound Care Healing and Hyperbaric, Department of Surgery, Northwell Health System, 270-05 76(th) Avenue, New Hyde Park, NY 11040. Electronic address:
Nonhealing wounds are increasingly prevalent, present in 1% to 2% of the global population, with higher incidence in geriatric patients. These chronic wounds pose challenges to older adult patients owing to physiologic changes that hinder healing, common medical comorbidities that promote inflammation and damage microcirculation, poor nutritional status and mobility, and psychosocial barriers to receiving care. In this literature review, the epidemiology, pathophysiology, systems costs, and management of chronic venous leg ulcers, arterial ulcers, and diabetic foot wounds in older adult patients are investigated.
View Article and Find Full Text PDFFront Pain Res (Lausanne)
August 2025
UR4391 (ENT Team), Faculty of Health, Paris Est Créteil University, Créteil, France.
J Pain Res
September 2025
Department of Pain, Zhejiang Jiashan County First People's Hospital, Jiaxing, Zhejiang, People's Republic of China.
Background: Parkinson's disease (PD) is a common neurodegenerative disorder of the central nervous system. Neuropathic pain (NP) is a type of symptom that is often overlooked but significantly affects the quality of life of patients. Its etiology is complex, and the specific molecular mechanism is still unclear.
View Article and Find Full Text PDFNeurol Ther
September 2025
Department of Neurosurgery, The General Hospital of Western Theater Command, Chengdu, China.
Central post-stroke pain (CPSP) is an intractable neuropathic pain syndrome. Dual-target deep brain stimulation (DBS), which integrates sensory thalamic modulation and endogenous analgesic pathways, has emerged as a potential intervention; however, clinical evidence remains scarce. We report a 54-year-old woman who developed right-sided limb paresthesia progressing to persistent right hemibody pain following a left thalamic hemorrhage.
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