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Article Abstract
Background: Non-invasive vagus nerve stimulation techniques show promise for modulating cortical networks, but their comparative effects during combined cognitive-swallowing tasks remain underexplored.
Aims: This feasibility study aimed to: (1) establish a protocol for assessing transauricular vagus nerve stimulation (taVNS) and VNMM effects using fNIRS during dual-task paradigms, and (2) compare their impacts on cortical activation and functional connectivity.
Methods: This protocol (ChiCTR2200065698) consisted of two separate blocks, a cognitive task ( = 25) and a swallowing task ( = 25), and healthy subjects in either block were randomly assigned to the taVNS and VNMM groups. The subjects underwent swallowing or cognitive task-state data acquisition before and after the trial intervention. The functional near-infrared spectroscopy (fNIRS) data were analyzed by generalized linear modeling (GLM) and seed-based correlation analysis to assess the cortical excitability and brain connectivity, and a BrainNet Viewer was used to visualize the intervention effects.
Results: Under the cognitive and swallowing task-state fNIRS protocols, both taVNS and VNMM significantly enhanced the activation effects and intra/inter-hemispheric brain network connectivity in the cognitive or swallowing-related brain regions ( < 0.05).
Conclusions: This study demonstrates the feasibility of using fNIRS to differentiate taVNS/VNMM effects during dual-task paradigms. Preliminary data suggest VNMM may offer superior network modulation, warranting larger trials to validate behavioral correlates.
Clinical Trial Registration: Chictr.org.cn, identifier: ChiCTR2200065698.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375658 | PMC |
| http://dx.doi.org/10.3389/fnins.2025.1619532 | DOI Listing |
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