Article Synopsis
- Multi-omics research showed that nanoplastics with different charges impact antibiotic resistance in bacteria like K12.
- Positively charged nanoplastics increased antibiotic resistance by activating genes related to stress tolerance and gene transfer, while negatively charged ones weakened biofilm formation and metabolism.
- This study underscores the importance of nanoplastic surface charge in influencing how microbes develop resistance, raising concerns about public health risks from nanoplastics.
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Article Abstract
Multi-omics approaches revealed how nanoplastics with different surface charges influence antibiotic resistance in K12. Positively charged nanoplastics enhanced antibiotic resistance by upregulating genes and proteins linked to oxidative stress tolerance and efflux pumps, and promoted antibiotic resistance genes transfer via conjugation and transformation. In contrast, negatively charged nanoplastics disrupted biofilm formation and metabolism, potentially reducing antibiotic resistance. These findings highlight the critical role of nanoplastics' surface properties in shaping microbial resistance dynamics and highlight emerging risks posed by nanoplastics to public health through accelerated antibiotic resistance propagation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12371250 | PMC |
| http://dx.doi.org/10.1002/imt2.70056 | DOI Listing |
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