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Background: To assess the safety and efficacy of a change to a stent first approach for malignant large bowel obstruction (LBO) in both left and right colon in a single centre over a 4-year period.
Methods: This retrospective cohort study in an acute NHS Hospital Trust from 01/01/2019-31/12/2022 examines a change in practice from emergency surgery (ES) to colonic stenting for patients with both left and right sided acute malignant LBO. Co-primary outcomes were clinically successful bowel decompression following stenting and 30-day mortality. Secondary outcomes were length of stay, stent complications, stoma formation and minimally invasive surgery (MIS).
Results: 68 patients underwent colonic stenting, and 29 patients underwent primary ES for acute malignant LBO. Stenting achieved successful bowel decompression in 77.9%. 30-day mortality for those initially stented was 7.4% and for ES 6.9%. In palliative patients initially treated with stenting the stoma rate was lower (15.4 vs. 100.0%) with a reduced rate of open surgery (5.1 vs 87.5%) when compared to ES. In curative patients initially treated with stenting the stoma rate was lower (37.9 vs. 80.1%) with an increased rate of MIS (69.0 vs 19.0%), when compared to ES. 27.9% of patients underwent stenting proximal to the splenic flexure.
Conclusions: It is possible to offer colonic stenting to > 80% of patients presenting with acute malignant LBO despite not having a 24/7 rota. There was a reduced rate of stoma formation, open surgery and length of stay in both palliative and curative patients undergoing primary colonic stenting.
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http://dx.doi.org/10.1007/s00464-025-12035-2 | DOI Listing |
Neurol Neuroimmunol Neuroinflamm
November 2025
Department of Neurology, UC Davis Medical Center, Sacramento, CA.
Objectives: Complement factor I (CFI) deficiency is a rare condition that can present with fulminant relapsing CNS autoinflammation. In this report, we highlight the utility of genetic testing in unexplained CNS autoinflammation.
Methods: This case report describes a young adult with partial CFI deficiency, presenting with acute hemorrhagic leukoencephalitis and longitudinally extensive transverse myelitis.
Med Oncol
September 2025
Division of Hematology and Blood Bank, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Acute Myeloid Leukemia (AML) patient-derived Mesenchymal Stem Cells (MSCs) behave differently than normal ones, creating a more protective environment for leukemia cells, making relapse harder to prevent. This study aimed to identify prognostic biomarkers and elucidate relevant biological pathways in AML by leveraging microarray data and advanced bioinformatics techniques. We retrieved the GSE122917 dataset from the NCBI Gene Expression Omnibus and performed differential expression analysis (DEA) within R Studio to identify differentially expressed genes (DEGs) among healthy donors, newly diagnosed AML patients, and relapsed AML patients.
View Article and Find Full Text PDFLung
September 2025
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Introduction: Lactate has emerged as a multifunctional signaling molecule regulating various physiological and pathological processes. Furthermore, lactylation, a newly identified posttranslational modification triggered by lactate accumulation, plays significant roles in human health and diseases. This study aims to investigate the roles of lactate/lactylation in respiratory diseases.
View Article and Find Full Text PDFAnal Chem
September 2025
Department of Laboratory Medicine, Fujian Medical University, Fuzhou 350004, China.
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children. Current clinical diagnosis primarily relies on invasive detection methods, while molecular subtyping remains a complex and time-consuming process. This study innovatively employed silver nanoparticle-based surface-enhanced Raman spectroscopy (SERS) technology to systematically analyze 116 serum samples, including those with breakpoint cluster region-Abelson (-) fusion genotype, mixed-lineage leukemia (, also known as lysine methyltransferase 2A, ) gene rearrangement subtype, T-lymphoblastic ALL, and healthy controls.
View Article and Find Full Text PDFCochrane Database Syst Rev
September 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Background: Radiotherapy is the mainstay of treatment for head and neck cancer (HNC) but may induce various side effects on surrounding normal tissues. To reach an optimal balance between tumour control and toxicity prevention, normal tissue complication probability (NTCP) models have been reported to predict the risk of radiation-induced side effects in patients with HNC. However, the quality of study design, conduct, and analysis (i.
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