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This study critically examines the cognitive and theoretical foundations of the alpha parameter within the Lévy flight model (LFM), an extension of the diffusion decision model (DDM) that incorporates heavy-tailed noise distributions. The alpha parameter, which modulates the tail of these distributions, is assessed for its test-retest reliability - an essential criterion for its classification as a cognitive style measure. Utilizing data from three previous studies, we observed that alpha demonstrates consistent reliability across tasks and time points, supporting its role as a trait-like characteristic. Our observation regarding the interrelations between LFM parameters showed that although most parameters exhibited weak correlations, reflecting their representation of distinct aspects of data, moderate correlations were observed between alpha and both threshold and non-decision time. Furthermore, investigating practice effects, we observed consistent reductions in non-decision time, threshold, and often alpha across sessions, accompanied by a corresponding increase in drift rate in demanding tasks. Notably, alpha showed a strong relationship with the mean reaction time of error responses, indicating its critical role in explaining fast error responses. Additionally, our examination of the predicted decision-time distribution found that lower alpha values correspond to shorter response times in the first quartile of both correct and error responses, highlighting its impact on capturing the dynamics of fast decision-making. Employing the BayesFlow framework for parameter estimation, we evaluated its precision across varying trial counts. These findings offer insights for future research on LFM and similar models.
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http://dx.doi.org/10.3758/s13428-025-02784-2 | DOI Listing |
Spectrochim Acta A Mol Biomol Spectrosc
September 2025
College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450001, PR China.
The interactions of three berberine mid-chain fatty acid salts ([BBR][C], n = 6, 7, 8) with lysozyme (Lyz) are investigated in detail using multi-spectroscopic and molecular docking techniques. Steady-state fluorescence and UV-visible absorption experiments suggest that the binding mechanism of [BBR][C] on Lyz is a static quenching with a binding ratio of 1:1. The compound [BBR][C] exhibits a moderate binding affinity toward Lyz.
View Article and Find Full Text PDFJ Anim Sci
September 2025
Department of Animal Science, South Dakota State University, Brookings, SD 57007, USA.
Flaxseed oil contains elevated levels of omega-3 fatty acids (n-3 FA), which have been shown to impact reproductive performance. This study aimed to determine the effects of a flaxseed oil-based supplement on reproductive parameters, feeding behavior, and lipid profile in beef heifers. Sixty Angus and Simmental × Angus heifers (14 months old ± 2 months), blocked by full body weight (BW; 396.
View Article and Find Full Text PDFJ Behav Med
September 2025
Department of Psychology and Human Development, Vanderbilt University, 230 Appleton Place, Nashville, TN, 37203‑5721, USA.
Estimating statistical power is essential for designing behavioral medicine studies efficiently and conserving finite resources. Sometimes behavioral medicine researchers are interested in calculating power for 1-sided z-tests of individual parameters (e.g.
View Article and Find Full Text PDFDiabetologia
September 2025
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Aims/hypothesis: Alpha cell dysregulation is an integral part of type 2 diabetes pathophysiology, increasing fasting as well as postprandial glucose concentrations. Alpha cell dysregulation occurs in tandem with the development of insulin resistance and changes in beta cell function. Our aim was to investigate, using mathematical modelling, the role of alpha cell dysregulation in beta cell compensatory insulin secretion and subsequent failure in the progression from normoglycaemia to type 2 diabetes defined by ADA criteria.
View Article and Find Full Text PDFJ Med Chem
September 2025
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, Third Section of Renmin South Road, Chengdu 610041, China.
Rheumatoid arthritis (RA) is a systemic autoimmune disease, and a large number of patients do not respond well to existing treatment strategies. Our previous report has discovered that the cyclic lipopeptide (CLP) daptomycin (DAP) has a good suppressive arthritis activity in mice. In this study, we have designed and synthesized five novel DAP-derived CLPs by structural optimization on the loop of DAP and further studied their anti-RA effects in vitro and in vivo.
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