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http://dx.doi.org/10.1038/s41598-025-16583-4 | DOI Listing |
As integrated circuit (IC) manufacturing advances toward smaller technology nodes, conventional lithography methods are increasingly challenged by the diffraction-limited resolution, escalating process complexity, and rising costs. Among these challenges, overlays have a particularly pronounced impact on manufacturing quality. To address this issue, this paper proposes a high-order overlay correction model that employs a two-dimensional fifth-order polynomial to accurately fit and characterize the distribution of overlays.
View Article and Find Full Text PDFFront Pediatr
August 2025
Department of Cardiac Surgery, Hebei Children's Hospital, Shijiazhaung, Hebei, China.
Common pulmonary vein atresia (CPVA) is a rare congenital heart disease characterized by the absence of functional connectivity between the pulmonary vein and any other heart cavity or systemic venous structure. A 13-h-old newborn (G3P3) was admitted to the department of pediatrics of a local maternity hospital and given tracheal intubation ventilator for assisted breathing due to systemic cyanosis, respiratory distress, and poor response 4 h after birth. He was transferred to Handan Maternal and Child Health Hospital 7 h after birth.
View Article and Find Full Text PDFNAR Genom Bioinform
September 2025
DNA Repair and Recombination Laboratory, St Vincent's Institute of Medical Research, Fitzroy VIC 3065, Australia.
Meiotic crossovers promote correct chromosome segregation and the shuffling of genetic diversity. However, the measurement of crossovers remains challenging, impeding our ability to decipher the molecular mechanisms that are necessary for their formation and regulation. Here we demonstrate a novel repurposing of the single-nucleus Assay for Transposase Accessible Chromatin with sequencing (snATAC-seq) as a simple and high-throughput method to identify and characterize meiotic crossovers from haploid testis nuclei.
View Article and Find Full Text PDFFront Neurol
August 2025
Unit of Child Neurology and Psychiatry, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Introduction: Restless Legs Syndrome (RLS), known as Willis-Ekbom disease, is a common neurological condition that often goes undiagnosed, especially in children. Characterized by an irresistible urge to move the legs, it is typically more pronounced in the evening and at rest. Growing Pains (GP), common in childhood and associated with migraine, present apparently overlapping symptoms with RLS, making it sometimes difficult to distinguish between the two.
View Article and Find Full Text PDFMater Today Bio
October 2025
Radboud University Medical Center, Research Institute for Medical Innovation, Department of Medical BioSciences, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.
Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.
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