98%
921
2 minutes
20
Due to urbanization and modern lifestyle, most of women in today's world are prone to Polycystic Ovarian Syndrome (PCOS), which is a hormonal disorder. Though the symptoms shown by this disease are often uncared, it seriously affects the reproductive health of women. Early detection of PCOS helps in managing several other attributes that are closely related to it. This article aims to study the impact of Vitamin D3 in PCOS and non-PCOS individuals. The goal is attained by building a tailored dataset with 1368 records and 43 attributes. Initially, the acquired dataset is pre-processed by handling missed values, outlier detection and data balancing by employing Probabilistic Principal Component Analysis (PPCA), Interquartile Range (IQR), Z-score standardization and SMOTE respectively. The significant features are selected by exploring different approaches such as filter based (Chi-Square, ANOVA), wrapper based (Electric Eel Foraging Optimization Algorithm) and embedded methods (LASSO, XGBoost). The selected features are utilized to train classifiers such as Random Forest (RF), k-Nearest Neighbour (k-NN), Decision Tree (DT) and Support Vector Machine (SVM). The experimental results show that the performance of EEFOA with RF prove the best accuracy rates of 98.8% with a F-measure of 98.19%. Explainable Artificial Intelligence (XAI) techniques such as SHAP and LIME are then employed to showcase the feature importance. It is observed that over 40% of PCOS patients are affected by deficiency and insufficiency of vitamin D3.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381069 | PMC |
http://dx.doi.org/10.1038/s41598-025-14728-z | DOI Listing |
Front Immunol
August 2025
Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
[This corrects the article DOI: 10.3389/fimmu.2023.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
September 2025
Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming City, Yunnan Province, 650000, China. Electronic address:
Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by ovarian dysfunction, with limited effective treatments. This study investigates the therapeutic effects and mechanisms of white kidney bean extract (WKBE) in a PCOS rat model. A PCOS model was established using letrozole, followed by intervention with varying doses of WKBE.
View Article and Find Full Text PDFComput Biol Chem
September 2025
Department of Bioengineering and Biotechnology, Birla Institute of Technology, Mesra, Ranchi, India. Electronic address:
Women are susceptible to hormonal imbalances and endocrine-related disorders such as Polycystic Ovary Syndrome (PCOS), Ovarian Cancer (OC), and Major Depressive Disorder (MDD). This study aims to identify gene-level interconnections among these conditions using omics-based bioinformatic approaches. Publicly available GEO datasets, viz.
View Article and Find Full Text PDFPediatr Ann
September 2025
Pediatric Gynecology Program, Children's National Hospital, Washington, DC.
Abnormal uterine bleeding (AUB), a common gynecologic concern in adolescents, often leads to significant physical and emotional distress. This article provides a comprehensive overview of AUB in adolescence, including classification, common causes, diagnosis, and management. The physiology of the hypothalamic-pituitary-ovarian axis is reviewed, highlighting its role in menstrual regulation and the immaturity-related anovulation that commonly contributes to AUB in the first 2 to 3 years after menarche.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, Khwaja Yunus Ali Medical College, Sirajganj, BGD.
Endometrial carcinoma is one of the most common gynecologic cancers worldwide. The condition typically occurs after menopause; however, young women under the age of 40 years can also be diagnosed with the disease. Providers may delay diagnosis in young patients due to nonspecific presentation or low clinical suspicion.
View Article and Find Full Text PDF