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http://dx.doi.org/10.1007/s10142-025-01652-8 | DOI Listing |
Mol Psychiatry
September 2025
Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Università degli Studi di Milano, Milan, Italy.
Early-life experiences shape neural networks, with heightened plasticity during the so-called "sensitive periods" (SP). SP are regulated by the maturation of GABAergic parvalbumin-positive (PV+) interneurons, which become enwrapped by perineuronal nets (PNNs) over time, modulating SP closure. Additionally, the opening and closing of SP are orchestrated by two distinct gene clusters known as "trigger" and "brake".
View Article and Find Full Text PDFComput Med Imaging Graph
August 2025
Institute of Advanced Technology, Zhejiang University of Technology, Hangzhou, China. Electronic address:
The segmentation of cranial nerves (CNs) tract provides a valuable quantitative tool for the analysis of the morphology and trajectory of individual CNs. Multimodal CN segmentation networks, e.g.
View Article and Find Full Text PDFDes Codes Cryptogr
April 2025
Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, the Netherlands.
This paper builds a novel bridge between algebraic coding theory and mathematical knot theory, with applications in both directions. We give methods to construct error-correcting codes starting from the colorings of a knot, describing through a series of results how the properties of the knot translate into code parameters. We show that knots can be used to obtain error-correcting codes with prescribed parameters and an efficient decoding algorithm.
View Article and Find Full Text PDFMethods Enzymol
August 2025
Plant Biochemistry, Faculty of Biology and Biotechnology, Ruhr-University Bochum, Bochum, Germany. Electronic address:
The N-terminus of a protein has an important regulatory impact on its in vivo stability and half-life. Proteins destined to chloroplasts and mitochondria are synthesized as precursor proteins in the cytosol with an N-terminal peptide sequence that ensures their correct targeting. During their cytosolic passage, precursor proteins are exposed to the cytosolic protein degradation machinery, hence, their N-termini must comply with regulatory processes for proteolytic degradation in the cytosol.
View Article and Find Full Text PDFGeroscience
August 2025
Psychology, School of Social Sciences, Nanyang Technological University, Singapore, 639818, Singapore.
Two decades of task-based fMRI studies have revealed atypical task-related activation and hypoactivation patterns in Alzheimer's disease (AD) and mild cognitive impairment (MCI), implicating the impaired cognitive processing observed in these neurocognitive disorders. The current coordinate-based meta-analysis provides an updated picture of the pathophysiological neurocognitive mechanisms implicated in MCI and AD, which better controls for false positive findings. To pool and summarise these findings, we conducted activation likelihood estimation (ALE) meta-analyses on 90 eligible studies (N = 2824) with cluster-level family-wise error correction to compare AD/MCI and healthy controls (HC) on fMRI activity during cognitive tasks across four different domains.
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