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Article Abstract
A visible-light-induced cascade radical fluoroalkylation/cyclization of -hydroxyaryl enaminones/2-(allyloxy)benzaldehydes with CFBr/1,2-dibromotetrafluoroethane in the presence of -Ir(ppy) and KHPO has been developed, which efficiently provides 3-fluoroalkyl-substituted chromone and chroman-4-one derivatives in good yields. In particular, the industrially available and low cost CFBr and 1,2-dibromotetrafluoroethane are used as fluoroalkyl reagents in this process, endowing the process with the potential to be used on a large scale. The mechanism was proposed based on the control experiments. The protocol also has the advantages of broad substrate scope and green energy source.
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