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Introduction: Limb-length discrepancies (LLDs) have traditionally been treated with external fixators, but magnetically driven intramedullary nails (MILNs) are increasingly favored for improved comfort and reduced infection risk. This study compared intramedullary (IM) versus extramedullary (EM) lengthening nails in pediatric patients with narrow femoral canals to evaluate mechanical axis deviation, nail bending, tourniquet time, and complications.
Methods: A retrospective, single-center review was conducted of 75 pediatric patients who underwent femoral lengthening between 2015 and 2022, each with at least two years of follow-up. Patients received either an 8.5 mm IM nail or a 10.7/12.5 mm EM nail, combined with a solid, threaded IM nail for stability. Outcomes included preoperative and postoperative limb alignment (MAD, mLDFA, and mPDFA), IM nail bending, operative details (tourniquet time and blood loss), consolidation times, and complication rates classified according to the Cherkashin system.
Results: Forty-two patients were treated with EM nails and 33 with IM nails. Both groups achieved similar distraction amounts (4.7 ± 1.1 cm) and consolidation intervals (7 to 8 mo). However, the EM group demonstrated significantly greater postoperative MAD (12.9 ± 9.5 mm vs. 8.7 ± 7.3 mm, P <0.05), higher nail bending (2 vs. 1.2 degrees, P<0.05), and longer tourniquet use. Overall complication rates were 69% (EM) and 60% (IM), with delayed union and soft tissue infection being the most frequent issues. Unplanned reoperations occurred in 21% of patients overall.
Conclusion: Both nail types correct limb‑length discrepancy, but extramedullary nails demand longer tourniquet times and have higher bending (of the IM component of the EM construct) and complication rates. Implant choice must suit patient factors and further comparative studies are warranted.
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http://dx.doi.org/10.1097/BPO.0000000000003079 | DOI Listing |
Food Funct
September 2025
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
: The therapeutic potential of vegetarian diets in metabolic dysfunction-associated steatotic liver disease (MASLD) remains understudied in Asian populations. This randomized controlled trial aimed to evaluate the effects of a culturally adapted 6-month lacto-ovo-vegetarian diet (LOV-D) on hepatic steatosis and cardiometabolic risk factors through weight loss. : In this randomized trial, 220 Chinese adults with MASLD were assigned to LOV-D ( = 110) or an omnivore diet ( = 110) for 6 months.
View Article and Find Full Text PDFThyroid
September 2025
Department of Molecular Diagnostics, Department of Endocrinology, The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
is a major cause of congenital hypothyroidism (CH) in Chinese patients, but clinical outcomes for those with biallelic mutations remain unclear. This study aimed to describe the clinical manifestations of CH due to defect. One hundred eighty-one patients with primary CH were recruited initially and were subjected to genetic screening.
View Article and Find Full Text PDFHistol Histopathol
September 2025
Institute of Pathology, University Hospital Bonn, Bonn, Germany.
Aims: We aimed to analyze CD63, a cell surface protein that has been associated with tumor aggressiveness in several cancers, including breast, colorectal, and lung cancer, as well as melanoma, in prostate cancer.
Methods: CD63 expression was analyzed immunohistochemically in a cohort of primary prostate cancers from 281 patients. The results were correlated with clinico-pathologic parameters, including biochemical recurrence.
J Pain Palliat Care Pharmacother
September 2025
Spine Unit, Orthopaedic Surgery and Traumatology Department, Catholic University and Polytechnic Hospital, Valencia, Spain.
Dexmedetomidine (DEX) has been proposed as an opioid-sparing adjunct after spinal fusion, but its efficacy across age groups is unclear. We conducted a systematic review and meta-analysis following PRISMA and registered in International Prospective Register of Systematic Reviews (PROSPERO) (CRD42024531252). Twelve studies (RCTs and cohorts; n=1,644) were included.
View Article and Find Full Text PDFHematology
December 2025
Thalassaemia International Federation (TIF), Nicosia, Cyprus.
Objective: The complexity of β-thalassaemia with associated morbidity, lifelong daily expensive treatment, and multidisciplinary care results in a considerable disease burden. Our study aimed to revisit the β-thalassaemia burden using epidemiological, clinical, and financial indicators related to patients, families, and healthcare systems.
Methods: Patient density measures, transfusion indices, complication rates, universal health coverage, and other indicators were tabulated by country and region.