Safety and Efficacy of Dexmedetomidine in Spinal Fusion: A Systematic Review and Meta-Analysis Dexmedetomidine in Spinal Fusion Surgery.

Dexmedetomidine (DEX) has been proposed as an opioid-sparing adjunct after spinal fusion, but its efficacy across age groups is unclear. We conducted a systematic review and meta-analysis following PRISMA and registered in International Prospective Register of Systematic Reviews (PROSPERO) (CRD42024531252). Twelve studies (RCTs and cohorts; n=1,644) were included.

Profiles of survival prediction in glioblastoma.

Introduction: Glioblastomas are aggressive brain tumors. While the extent of resection of contrast-enhancing-tumor on MRI correlates with improved survival, the prognostic value of other tumor compartments remains unclear.

Research Question: We aimed to find neuroimaging predictive profiles related to postoperative outcomes.

Robot-assisted lumbar fixation in single lateral position: OLIF L4-5, ALIF L5-S1, and L4-S1 percutaneous pedicle screws.

The integration of robot-assisted spine surgery (RASS) and single lateral position surgery (SLPS) has revolutionized spinal fusion by enhancing efficiency, reducing surgical time, and improving patient outcomes. This video demonstrates a step-by-step procedural workflow for robot-assisted OLIF L4-L5, ALIF L5-S1, and percutaneous pedicle screw fixation (L4-S1) in a single lateral decubitus position using the ExcelsiusGPS system. The workflow highlights preoperative CT-based planning, intraoperative image fusion, real-time navigation, and robot-guided implant placement.

Surgical outcomes in octogenarian meningioma patients: a multicenter retrospective analysis of frailty and radiological predictors : Frailty in octogenarians undergoing meningioma resection.

Background: The rising life expectancy has led to an increased incidence of meningiomas among the elderly. In octogenarians, surgical decision-making remains particularly challenging due to frailty, comorbidities, and the risk of postoperative decline. This study investigates whether preoperative frailty indices and radiological features predict surgical outcomes in this high-risk population.

Pharmacological evaluation of non-nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury.

Background And Purpose: Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage-associated molecular patterns, such as ATP release, recognised by P2X7 receptors. The P2X7-NLRP3 inflammasome axis has been identified as one of the main players in neuroinflammation.

Clinical Impact of a Next-Generation Sequencing Approach for Glioblastoma Patients.

The purpose of this study is to assess the clinical impact of next-generation sequencing (NGS), as an increasingly available and advantageous tool, for glioblastoma patients. Adult patients aged less than 65, and surgically treated for glioblastoma between 2010-2021, were included. Tumor samples were analyzed with NGS using the Oncomine Comprehensive v3 (OCA) panel and Ion Reporter Genexus v5.

Robotic spine surgery: Technical note and descriptive analysis of the first 40 cases.

Introduction: The global incidence of spinal pathology is increasing due to the progressive aging of the population and increased life expectancy. Vertebral fixation with transpedicular screws is the most commonly used technique in unstable or potentially unstable pathologies. There are different implantation methods, the most recently developed being implantation guided by robotic navigation.

hyperinfection syndrome due to corticosteroid therapy after resection of meningioma: illustrative case.

Background: Strongyloidiasis is an underdiagnosed and preventable life-threatening disease caused by infection with the helminth . Chronic asymptomatic infection can be sustained for decades, and immunosuppression can lead to disseminated infection, with a mortality rate of 70%-100%. In the neurosurgical population, corticosteroids are the most consistent cause of hyperinfection.

Treatment of cervical myelopathy by posterior approach: Laminoplasty vs. laminectomy with posterior fixation, are there differences from a clinical and radiological point of view?

Introduction: Cervical degenerative myelopathy is a variable and progressive degenerative disease caused by chronic compression of the spinal cord. Surgical approaches for the cervical spine can be performed anteriorly and/or posteriorly. Regarding the posterior approach, there are 2 fundamental techniques: laminoplasty and laminectomy with posterior fixation (LPF).

H3K27M-mutant glioma in thoracic spinal cord and conus medullaris with pilocytic astrocytoma morphology: case report and review of the literature.

Background: The H3K27M-mutant spinal cord gliomas are very aggressive with a dismal prognosis, very few cases have been reported in the thoracic spinal cord and conus medullaris, and it is extremely rare with morphological features of pilocytic astrocytoma.

Case Presentation: A 20-year-old man presented with thoracolumbar pain, progressive paraparesis, and urinary incontinence. Magnetic resonance imaging revealed an intramedullary solid-cystic lesion from D9 to conus medullaris.

Case Report: Decompressive Craniectomy for COVID-19 Malignant Cerebral Artery Infarction. Is Surgery a Good Option?

SARS-CoV2 infection can lead to a prothrombotic state. Large vessel occlusion, as well as malignant cerebral stroke have been described in COVID-19 patients. In the following months, given the increase in COVID-19 cases, an increase in malignant cerebral SARS-CoV2 associated strokes are expected.

Seven Microaneurysms: Description of an Experimental Rodent Model for Neurovascular Training.

Aim: To demonstrate the microsurgical procedures, and to evaluate the feasibility of living models of experimental neurovascular training by developing new complex vascular exercises mimicking the most common intracranial aneurysms.

Material And Methods: The procedures were performed under a Zeiss (OPMI pico f170) microscope using basic microsurgery instruments, 10/0 Nylon and blue Polypropylene micro-sutures. We selected adult albino Wistar rats weighing between 258 and 471g each.