Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Subjective Cognitive Decline (SCD) is recognized as one of the earliest symptoms of Alzheimer's Disease (AD), the leading cause of dementia. However, factors influencing SCD are inconsistent across studies, with limited research on the risk associated with combinations of symptoms, particularly anxiety and depression.
Methods: This propensity score-matched case-control study analyzed data from the National Essential Public Health Service Program in Shenzhen, China. A total of 270,148 participants aged 65 and older underwent assessments in 2022. Among them, 10,471 participants with SCD were identified as the study group, matched with an equal number of controls without SCD. The match was based on age, gender, household registration, occupation, marital status, and education level. Conditional logistic regression models identified influencing factors and evaluated risks associated with various mental health symptom combinations. Parallel mediation analysis was employed to assess the mediating role of anxiety and depressive symptoms between key factors and SCD.
Results: The identified risk factors for SCD included diabetes (AOR: 1.12, 95 %CI: 1.04-1.21), anxiety symptoms (8.49, 6.64-10.90), depressive symptoms (8.06, 5.10-12.80), past smokers (1.20, 1.07-1.34), and occasional alcohol consumption (1.14, 1.03-1.26). Conversely, daily exercise (0.71, 0.66-0.77) and occasional exercise (0.76, 0.68-0.84) were associated with a reduced risk of SCD. Anxiety and depressive symptoms also served as mediators between exercise and SCD. The comorbidity of anxiety and depressive symptoms posed the highest risk for SCD (19.70, 10.70-36.20).
Conclusions: These findings highlight the significant role of anxiety and depressive symptoms, particularly their comorbidity, in identifying individuals at high risk for SCD. Early screening and targeted interventions may help mitigate cognitive decline and promote healthy aging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jad.2025.120099 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dapagliflozin Reverses LPS-Induced Depressive-Like Behavior in Mice via Modulation of Glutamate and NF-κB.
Genes Brain Behav
October 2025
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Major depressive disorder is a prevalent and debilitating psychiatric illness that produces significant disability. Clinical data suggest that the pathophysiology of depression is due, in part, to a dysregulation of inflammation and glutamate levels in the brain. The systemic administration of lipopolysaccharide (LPS) has been shown to induce depressive-like behaviors in mice.
View Article and Find Full Text PDFParental emotion socialization and internalizing problems in childhood and adolescence: A meta-analytic review.
Dev Psychopathol
September 2025
Department of Psychological Sciences, Kent State University, Kent, OH, USA.
Anxiety and depression symptoms and disorders are the leading child mental health problems in western societies. This systematic review evaluated how parental emotion socialization (ES) relates to children's internalizing problems (from birth to age 18 years). Three meta-analyses, evaluating supportive ( = 50, = 10,698), nonsupportive ES behaviors ( = 47, = 10,970), and elaboration ( = 6, = 867) were conducted.
View Article and Find Full Text PDFTrends and Disparities in Poststroke Depression Within 1 Year of Ischemic Stroke.
J Neuropsychiatry Clin Neurosci
September 2025
Departments of Radiology, Neurology, and Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY.
Objective: One of the most frequent neuropsychiatric complications after a stroke is poststroke depression (PSD). However, it is unclear whether disparities exist in PSD diagnosis. The authors examined a 10-year trend in PSD by socioeconomic and clinical characteristics.
View Article and Find Full Text PDFResting-State Functional Connectivity and Alcohol Use Disorder: A Case-Control Study.
J Neuropsychiatry Clin Neurosci
September 2025
Department of Psychiatry and Behavioural Neurosciences, McMaster University and Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON.
Objective: The authors examined differences in resting-state functional connectivity (rsFC) in the brain between nontreatment-seeking adults with alcohol use disorder (case group) and recreational drinkers without alcohol use disorder (control group) and explored behavioral and psychological mechanisms underlying these differences.
Methods: This case-control study included 140 adults (N=71 with alcohol use disorder and N=69 demographically matched control individuals) who completed a 9-minute resting-state functional MRI scan. About 45% were men, and the mean±SD age was 32.
Is every pancreatic cancer patient a palliative care patient?
Ann Palliat Med
September 2025
Brown University Health Cancer Institute, Providence, RI, USA; Division of Geriatrics and Palliative Medicine, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, US.
ancreatic cancer is an aggressive disease and often presents at an advanced stage with no curative options. The disease is often characterized by rapid progression, limited or short-lived responsiveness to standard therapies, and a profound impact on patients' quality of life. Despite advances in targeted therapies and immunotherapy, curative outcomes remain elusive for the majority of patients with advanced or high-grade disease with a 5-year survival rate of less than 10%.
View Article and Find Full Text PDF