98%
921
2 minutes
20
Introduction: The uptake of direct-acting antiviral (DAA) is suboptimal among people who use drugs (PWUD) living with hepatitis C virus (HCV). However, innovative methods such as Rapid-Start DAA (RS-DAA) can expedite treatment initiation. We sought to explore the perspectives of HCV service providers, policy experts and PWUD to guide the development of an RS-DAA strategy in Malaysia.
Methods: Three separate focus groups were conducted in Klang Valley, Malaysia, using the Nominal Group Technique with HCV service providers, policy experts, and PWUD. These sessions included open questions, silent idea generation and individual round-robin feedback. Discussions were guided by Høj's framework on access to HCV care, and concluded with a structured voting process, through which participants generated a rank-ordered list of ideas to systematically inform the RS-DAA strategy.
Results: A total of 23 participants were recruited: HCV service providers (n = 10, working in primary and tertiary healthcare settings), policy experts (n = 5, from public health organizations), and PWUD (n = 8, with varied HCV treatment experiences). Service providers identified delays in receiving HCV RNA results as the top barrier. Policy experts emphasized limited testing capacity and concerns about outreach team's capabilities. PWUD cited time constraints due to work and family responsibilities. Potential solutions included enabling remote registration of new clients, improved laboratory coordination, and enhanced community awareness on HCV.
Conclusion: Addressing logistical challenges, fostering collaboration, and optimizing processes are essential for RS-DAA. The next step will involve revising the proposed protocol based on stakeholder feedback and moving towards its implementation.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.drugpo.2025.104966 | DOI Listing |
Biom J
October 2025
Novella Clinical Full Service, IQVIA, Melbourne, Australia.
Phase I dose escalation trials in oncology generally aim to find the maximum tolerated dose. However, with the advent of molecular-targeted therapies and antibody drug conjugates, dose-limiting toxicities are less frequently observed, giving rise to the concept of optimal biological dose (OBD), which considers both efficacy and toxicity. The estimand framework presented in the addendum of the ICH E9(R1) guidelines strengthens the dialogue between different stakeholders by bringing in greater clarity in the clinical trial objectives and by providing alignment between the targeted estimand under consideration and the statistical analysis methods.
View Article and Find Full Text PDFNutr Clin Pract
September 2025
Centre for Health Services Research, University of Queensland, Brisbane, Queensland, Australia.
Theoretical approaches can help to plan, guide, and evaluate implementation projects that target real-world practice problems. This paper provides an overview of the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework and summarizes its use in nutrition and dietetics research and practice. A narrative summary of its use was compiled from the published literature based on citations from two key reference sources of the i-PARIHS framework.
View Article and Find Full Text PDFBMC Nurs
September 2025
Institute of Business Administration and Business Informatics, IT for the Caring Society, University of Hildesheim, Hildesheim, Germany.
Background: As populations age, informal caregivers play an increasingly vital role in long-term care, with 80% of care provided by family members in Europe. However, many individuals do not immediately recognize themselves as caregivers, especially in the early stages. This lack of awareness can increase physical and emotional stress and delay access to support services.
View Article and Find Full Text PDFBMC Health Serv Res
September 2025
Center for Health Services Research, Brandenburg Medical School Theodor Fontane, Seebad 82/83, Rüdersdorf, 15562, Germany.
Background: Hypertension remains a critical public health issue in Germany, affecting millions of individuals. Mobile health applications (mHealth apps) offer promising solutions for improving patient outcomes and adherence in hypertension management. Despite their advantages in healthcare, the adoption of mHealth apps by general practitioners (GPs) in Germany remains limited to date.
View Article and Find Full Text PDFBMC Nurs
September 2025
Institute for Public Health and Nursing Research, Department Evaluation and Implementation Research in Nursing Science, University of Bremen, Grazer Straße 4, D- 28359, Bremen, Germany.
Background: School nursing is a complex clinical specialty practice that varies across different countries. Theories, models and frameworks can inform nursing practice. This scoping review aims to explore the conceptualisation and operationalisation of school nursing in theories, models and frameworks.
View Article and Find Full Text PDF