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Sekiguchi, Y, Jiwan, NC, Appell, CR, Moya, RM, Ky, AT, Keefe, MS, Dunn, RA, and Luk, H-Y. Impact of hydration status on sleep and recovery after heavy resistance exercise. J Strength Cond Res XX(X): 000-000, 2025-The purpose of this study was to examine the effects of hydration status on sleep and recovery measurements before and after heavy resistance exercise (RE). Eight resistance-trained men (age, 21 ± 2 years; body mass, 82.0 ± 12.6 kg; height, 177.3 ± 6.9 cm) performed bilateral leg press and knee extensions (5 sets of 10 repetitions at 80% of 1 repetition maximum, 2 minutes rest). Participants completed 1 trial in a euhydrated state (EUH; urine specific gravity [USG] < 1.020) and the other trial in a dehydrated state (DEH: USG ≥ 1.020), which was separated by 2 weeks. For the DEH trial, participants were restricted from consuming fluids for 24 hours before RE and were only permitted to drink 1.5 L of water after RE for the remainder of the day. For the EUH trial, participants were instructed to consume fluid for 24 hours before and 24 hours after RE to maintain euhydration. Sleep and recovery measurements were collected from a wearable sleep device that participants wore the night before (PRE) and after RE (POST). Repeated measures ANOVAs and linear mixed effect models were used to identify differences between EUH and DEH. Plasma osmolality, urine osmolality, USG, urine color, and body mass loss (p < 0.05) were significantly higher in DEH than in EUH. However, there were no differences between EUH and DEH in sleep duration, efficiency, disturbance, deprivation, slow wave sleep, rapid eye movement sleep, light sleep, awaking time, resting heart rate, and heart rate variability. In conclusion, acute dehydration might not affect sleep and recovery measurements the night before and after heavy resistance exercise.
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http://dx.doi.org/10.1519/JSC.0000000000005225 | DOI Listing |
Sci Adv
September 2025
Laboratory of Neurobiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Acute sleep deprivation (SD) rapidly alleviates depression, addressing a critical gap in mood disorder treatment. Rapid eye movement SD (REM SD) modulates the excitability of vasoactive intestinal peptide (VIP) neurons, influencing the synaptic plasticity of pyramidal neurons. However, the precise mechanism remains undefined.
View Article and Find Full Text PDFCureus
August 2025
Pharmacology, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Background Delirium and sleep disturbances are common in critically ill patients and are associated with adverse outcomes, including prolonged intensive care unit (ICU) stays. Ramelteon, a melatonin receptor agonist, may improve sleep and reduce delirium by regulating circadian rhythms. This study evaluated the efficacy of ramelteon in shortening ICU stay, decreasing delirium incidence and duration, and improving sleep quality in critically ill patients.
View Article and Find Full Text PDFJ Psychiatr Res
September 2025
Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, China. Electronic address:
Background: The duration of untreated psychosis (DUP) is a critical factor influencing long-term outcome in schizophrenia (SCZ). Its short-term effects during early treatment remain less well characterized.
Methods: We enrolled 300 drug-naïve SCZ patients, of whom 78 completed a 12-week evaluation with comprehensive clinical and functional assessments.
Elife
September 2025
Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show that interleukin-6-like cytokine signaling from the gut to brain glial cells regulates sleep. Under healthy conditions, this pathway promotes wakefulness.
View Article and Find Full Text PDFEur Spine J
September 2025
Hong Kong Polytechnic University, Hong Kong, China.
Purpose: The purpose of this study was to determine through a Delphi process a list of outcomes measures for clinicians to use when assessing individuals with Lumbar Spinal Stenosis (LSS).
Methods: A three-phase Delphi process was conducted by the International Society for the Study of the Lumbar Spine (ISSLS) Lumbar Spinal Stenosis Taskforce, including two online surveys, two virtual meetings, and three in-person consensus meetings at the ISSLS annual conferences (2023-2025). Participants evaluated and ranked outcome measures for LSS, with final endorsement requiring > 66% agreement.