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Background: Coronary artery bypass grafting (CABG) is frequently associated with postoperative arrhythmias, often necessitating temporary cardiac pacing (TCP). The routine placement of temporary epicardial pacing wires (PWs) remains controversial due to potential complications. This study aimed to identify predictors for TCP after isolated CABG to guide selective PW use and improve perioperative outcomes.
Methods: A retrospective analysis was conducted on 1,395 patients who underwent isolated CABG with cardiopulmonary bypass (CPB) at King Abdullah University Hospital, Jordan, between 2004 and 2022. Patients undergoing redo surgeries or presenting with high-grade atrioventricular block, ischemic ventricular septal defect, or missing data were excluded. Patients were grouped based on PW placement, and predictors for TCP were assessed using univariate and multivariate logistic regression.
Results: Among the 1,395 patients, 887 received PWs, and 127 required TCP. Significant predictors for TCP included preoperative bundle branch block (BBB), intraoperative blood transfusion, prolonged vasoactive support, and mechanical ventilation exceeding 12 hours postoperatively. Preoperative beta-blocker use was associated with reduced risk of TCP. Demographics, comorbidities, and prolonged CPB or aortic cross-clamp times were not significant.
Conclusion: Preoperative BBB and postoperative complications were associated with increased TCP risk, while beta-blocker use was protective. These findings support a risk-based strategy for PW placement after CABG to reduce complications and improve resource allocation. Prospective studies are needed to validate these predictors and refine perioperative protocols.
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http://dx.doi.org/10.2147/VHRM.S513921 | DOI Listing |
Vasc Health Risk Manag
August 2025
Department of Cardiology, MercyOne Iowa Heart Center, Des Moines, IA, USA.
Background: Coronary artery bypass grafting (CABG) is frequently associated with postoperative arrhythmias, often necessitating temporary cardiac pacing (TCP). The routine placement of temporary epicardial pacing wires (PWs) remains controversial due to potential complications. This study aimed to identify predictors for TCP after isolated CABG to guide selective PW use and improve perioperative outcomes.
View Article and Find Full Text PDFCancer Immunol Immunother
May 2025
Department of Gastroenterology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Background: Chaperonin containing TCP1 subunit 5 (CCT5), a vital component of the molecular chaperonin complex, has been implicated in tumorigenesis, cancer stemness maintenance, and therapeutic resistance. Nevertheless, its comprehensive roles in pan-cancer progression, underlying biological functions, and potential as a predictor of immunotherapy response remains poorly understood.
Methods: We performed a comprehensive multi-omics pan-cancer analysis of CCT5 across 33 cancer types, integrating bulk RNA-seq, single-cell RNA-seq (scRNA-seq), and spatial transcriptomics data.
Front Oncol
May 2025
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Background And Purpose: This study aimed to analyze the impact of interobserver variability (IOV) on clinical dosimetry and prognosis, specifically investigating the correlation between IOV and clinical prognosis in the context of intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC).
Materials And Methods: Twelve NPC patients who underwent IMRT were selected. Four radiotherapy physicians from two different-tier cancer centers independently delineated target volumes and organs at risk (OARs) for each patient.
Clin Exp Metastasis
April 2025
Department of Radiation Oncology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Liver metastases, a hallmark of systemic disease, carry a poor prognosis despite advancements in systemic therapies. Stereotactic body radiation therapy (SBRT) has emerged as a promising local treatment, offering durable tumor control with minimal toxicity. However, the optimal dosimetric strategies to maximize outcomes remain an area of active investigation.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
August 2025
From the Department of Trauma and Acute Care Surgery (J.S.L., E.J., N.H.S., V.B., T.J.S.), UCHealth Memorial Hospital, Colorado Springs; Department of Surgery (J.S.L., E.J., R.C.M., F.L.W., M.W.C.), University of Colorado Anschutz Medical Campus, Aurora; and Department of Trauma and Acute Care Surge
Background: Appropriate chemical prophylaxis can reduce the risk of venous thromboembolism (VTE) in trauma patients. A system-wide VTE clinical practice guideline (CPG) and electronic health record (EHR)-based VTE prophylaxis order set were implemented. The CPG provided guidelines based on bleeding risk, recommended earlier initiation of chemical prophylaxis, and favored low-molecular-weight heparin (LMWH).
View Article and Find Full Text PDF