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http://dx.doi.org/10.1016/j.gie.2025.08.014 | DOI Listing |
Cureus
August 2025
Mother and Child Health Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, MAR.
Congenital hyperinsulinism (CHI) is a rare but significant cause of persistent neonatal hypoglycemia (NH), associated with a high risk of neurological complications if not promptly treated. This condition is characterized by inappropriate insulin secretion, often of genetic origin, independent of blood glucose levels. We report the case of a male macrosomic newborn admitted on the second day of life for respiratory distress, generalized seizures, and severe hypoglycemia (1.
View Article and Find Full Text PDFDiabetes Obes Metab
September 2025
Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Aims: To determine the effectiveness and safety of early combination therapy with insulin degludec and intravenous insulin infusion (IVII) compared with IVII alone in diabetic ketoacidosis (DKA) management.
Materials And Methods: This prospective, open-label, randomised controlled trial included 80 adults (≥18 years) with DKA. Participants were randomised to either the intervention group, which received early subcutaneous (SC) insulin degludec (0.
Anim Sci J
September 2025
Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.
Elevated blood nonesterified fatty acids (NEFA) concentration in prepartum increases the risk of postpartum diseases. This study evaluated whether intraruminal propylene glycol (PG) or sucrose (SC) administration could mitigate elevated blood NEFA induced by intravenous lipid infusion. Four nonlactating, nonpregnant Holstein cows fitted with rumen cannulas were used in a 4 × 4 Latin square design: intravenous saline infusion and ruminal administration of water (S + WT), lipid infusion and administration of water (L + WT), lipid infusion and PG administration (L + PG), and lipid infusion and SC administration (L + SC).
View Article and Find Full Text PDFRisk Manag Healthc Policy
August 2025
Department of Emergency Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Purpose: This study evaluates the effectiveness of motorcycle ambulances (motorlances) in delivering emergency medical response at the Khon Kaen International Marathon (KKIM), Thailand, over a three-year period (2023-2025).
Patients And Methods: We conducted a retrospective analysis of emergency medical service (EMS) data from three consecutive annual Khon Kaen International Marathons held on January 28-29, 2023; January 13-14, 2024; and January 11-12, 2025. Data including EMS operation intervals, clinical interventions carried out, and patient outcomes were collected from EMS patient care documents, organized by Srinagarind Hospital, Khon Kaen University, Thailand during the marathon events.
Front Med (Lausanne)
August 2025
Department of Endocrinology, Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, China.
Objectives: The association between SARS-CoV-2 infection and endocrine emergencies (such as fulminant type 1 diabetes mellitus and subacute thyroiditis) has received increasing attention. However, concurrent manifestations of these two conditions within a short period of time after infection are exceedingly rare, and the underlying mechanisms and clinical management strategies remain unclear.
Case Presentation: A 45-year-old Chinese man developed sudden polydipsia, polyuria, and cervical pain on day 7, within 2 weeks of SARS-CoV-2 infection.