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Xanthogranulomatous cholecystitis (XGC) is an uncommon inflammatory disease of the gallbladder. We report a case of XGC with elevated activity of 18F-FDG and 68Ga-FAPI (fibroblast activating protein inhibitor), which mimics malignancy. Our case suggests that XGS should be considered in the differential diagnosis of cancer-like gallbladder lesions with increased 68Ga-FAPI uptake.
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http://dx.doi.org/10.1097/RLU.0000000000005984 | DOI Listing |
Diagnostics (Basel)
August 2025
Department of Gastroenterology, Nagoya City University Graduate School of Medical Sciences, Nagoya 458-0037, Japan.
Type 1 autoimmune pancreatitis (AIP), IgG4-related sclerosing cholangitis (IgG4-SC), and IgG4-related cholecystitis are recognized as IgG4-related pancreatobiliary diseases. Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography (EUS) are crucial diagnostic modalities for these conditions. In the diagnosis of AIP, EUS-guided tissue acquisition plays an important role in obtaining histological confirmation and excluding pancreatic cancer (PC).
View Article and Find Full Text PDFClin Nucl Med
August 2025
Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University.
Xanthogranulomatous cholecystitis (XGC) is an uncommon inflammatory disease of the gallbladder. We report a case of XGC with elevated activity of 18F-FDG and 68Ga-FAPI (fibroblast activating protein inhibitor), which mimics malignancy. Our case suggests that XGS should be considered in the differential diagnosis of cancer-like gallbladder lesions with increased 68Ga-FAPI uptake.
View Article and Find Full Text PDFEur J Radiol
October 2025
Department of Radiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200438, China. Electronic address:
Objectives: To evaluate the value of contrast-enhanced ultrasound (CEUS) combined with two-dimensional shear wave elastography (2D-SWE) in the differential diagnosis of xanthogranulomatous cholecystitis (XGC) and gallbladder carcinoma (GBC).
Methods: This study included 90 patients who underwent surgical treatment from December 2021 to September 2023. Pathological results divided them into XGC (22 cases) and GBC (68 cases) groups.
Intern Emerg Med
June 2025
Medical Point Hospital, Department of General Surgery, Gaziantep, Turkey.
Xanthogranulomatous cholecystitis (XGC) is a benign yet locally aggressive inflammatory condition that often mimics gallbladder adenocarcinoma (GBC) in clinical, radiological, and intraoperative presentation, leading to diagnostic uncertainty and potential overtreatment. This retrospective study aimed to identify distinguishing features between XGC and GBC by analyzing demographic, clinical, biochemical, radiological, and histopathological data from 133 patients who underwent cholecystectomy between 2013 and 2024. Among them, 115 were diagnosed with XGC and 18 with GBC.
View Article and Find Full Text PDFThe diagnosis of gallbladder (GB) lesions relies on imaging findings. Transpapillary cholangioscopy can potentially be used to diagnose GB lesions; however, the images obtained remain unclear. This study aimed to characterize the endoscopic findings of GB lesions.
View Article and Find Full Text PDF