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Monitoring and evaluating tumor ablation is a critical step in the treatment process. However, the traditional medical imaging methods used in surgeries often have some drawbacks, such as poor real-time performance (CT/MRI), low imaging accuracy (ultrasound), and the presence of radiation risks (X-ray imaging). This paper proposes a Central Drive Frequency Difference Electrical Impedance Tomography (CD-FDEIT) approach. This method utilizes intra-body ablation electrodes along with body surface electrodes to record impedance data. By applying a sweeping excitation, it aims to measure the impedance changes in the tumor ablation area during the operation, convert them into visual real-time images, and thereby monitor the progress of the tumor ablation surgery and assist doctors in conducting the surgery and making clinical decisions. Simulation results indicate that this method effectively captures real-time alterations in ablated tissues. The measuring system primarily consists of current-delivering intra-body electrodes embedded in the surgical instrument, alongside non-invasive body surface sensor electrodes. Physical model tests reveal that the optimal measuring frequencies for the real and imaginary components are 10kHz and 1MHz, respectively. The relative error (RE), correlation coefficient (CC), and structural similarity index (SSIM) achieved by the CD-FDEIT method were 0.392, 0.889, and 0.788, respectively, compared with the traditional EIT method, they have been improved by 5.1%, 4.4%, and 12.2% respectively, suggesting improved accuracy in tracking the ablation status of tumors and offering practical reference for clinical monitoring.
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http://dx.doi.org/10.1109/TBME.2025.3599067 | DOI Listing |
Anal Chem
September 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Deciphering the multicomponent of cell membranes at the single-cell level is critical for understanding pathological mechanisms such as tumor metastasis, yet remains technically daunting due to the membrane's nanoscale thickness and ultralow molecular abundance. Here, we introduce a surface-assisted vacuum ultraviolet laser desorption-ionization mass spectrometry imaging (SAVUVDI-MSI) platform that overcomes long-standing challenges of cytoplasmic interference and insufficient sensitivity. Leveraging the nanoscale depth profiling capability of VUV-LDI, we achieve precise ablation of a single-cell membrane.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
China-New Zealand Joint Laboratory on Biomedicine and Health, State Key Laboratory of Immune Response and Immunotherapy, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, GIBH-CUHK Joint Resea
TP53 mutations are highly associated with hepatocellular carcinoma (HCC), a common and deadly cancer. However, few primary drivers in the progression of HCC with mutant TP53 have been identified. To uncover tumor suppressors in human HCC, a genome-wide CRISPR/Cas9-based screening of primary human hepatocytes with MYC and TP53 overexpression (MT-PHHs) is performed in xenografts.
View Article and Find Full Text PDFFront Surg
August 2025
Breast Unit, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
Background: Breast cysts are more common in premenopausal women (61.5%), particularly between ages 35-50. Microwave ablation (MWA) has shown advantages in treating symptomatic cysts.
View Article and Find Full Text PDFIndian J Endocrinol Metab
August 2025
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Tumour-induced osteomalacia (TIO) is rare. At our referral centre, we see a substantial number of TIO. Therefore, we planned to study their profile and treatment outcomes to provide insight in management.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Perylene diimide (PDI) radical anions have attracted increasing attention as hypoxia-responsive photothermal agents due to their strong near-infrared (NIR) absorption and efficient photothermal conversion. However, their biomedical application is often limited by aggregation-induced quenching and poor structural tunability. In this work, we report a rationally engineered four-arm PDI derivative (PDI-4Alky·4Cl) bearing terminal alkyne groups, which not only suppresses π-π stacking steric and electrostatic repulsion, but also serves as a versatile molecular scaffold for further functionalization.
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