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Purpose: This study aimed to compare the accuracy of orthodontic tooth movements achieved with three-dimensionally (3D) printed aligners (Noxi, Sweden&Martina, Due Carrare, Padova, Italy) using a 12 h/day protocol with that of thermoformed aligners (F22 aligner, Sweden&Martina, Due Carrare, Padova, Italy) using a 22 h/day protocol.
Methods: Of the 40 white adult patients (12 men and 28 women, mean age 30.1 years) undergoing orthodontic treatment with aligners selected based on specific inclusion criteria, 20 patients were treated with Noxi aligners using a 12 h/day protocol (study group), and the remaining 20 patients were treated with F22 aligners using a 22 h/day protocol (control group). Pretreatment, ideal posttreatment (as planned in the setup), and real posttreatment digital models were analyzed using VAM software (Vectra, Canfield Scientific, Fairfield, NJ, USA). Angular and linear measurements were evaluated to measure mesiodistal tipping, vestibulolingual tipping, and rotational movements for 1120 teeth. Data were compared to evaluate treatment accuracy for each tooth, with statistical analysis of the results.
Results: No statistically significant differences in accuracy emerged between the study group (64.2%) and the control group (65.4%) for any type of tooth movement or tooth category. In the study group, vestibulolingual tipping showed the highest predictability (69.63%), followed by mesiodistal tipping (65.38%) and rotation (60.5%). In the control group, the vestibulolingual and mesiodistal movements showed the highest predictability, with a mean accuracy of about 67%, followed by rotation (62.3%).
Conclusion: Despite the reduced collaboration request, the group treated with Noxi aligners did not show any significant differences compared to the group treated with F22 aligners with regard to percentage accuracy for all analyzed orthodontic movements.
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http://dx.doi.org/10.1007/s00056-025-00609-7 | DOI Listing |
J Neurol Neurosurg Psychiatry
July 2025
The Alfred, Melbourne, Victoria, Australia.
Background: Corticosteroid treatment of multiple sclerosis (MS) relapses is assumed to improve the speed of relapse recovery, without modifying long-term disability risk. We aimed to re-evaluate this assumption in a large cohort of individuals with MS.
Methods: Individuals with clinically definite MS and ≥3 Expanded Disability Status Scale (EDSS) measurements over ≥12 months were identified within the international neuroimmunology registry MSBase.
BMJ Open
July 2025
Data Science Department, SESAN, Paris, France.
Purpose: The SEV-IDF programme aims to track infants born before 33 weeks of gestation, with very low birth weight (VLBW), neonatal encephalopathy or severe birth anomalies and perinatal disease. It employs an open, prospective, multicentric, population-based cohort approach. This report aims to describe the methodology employed to establish and manage the programme, details regarding follow-up procedures, baseline characteristics of the included infants, and highlights new research opportunities emerging from the "" (SEV-IDF) programme.
View Article and Find Full Text PDFAllergy
August 2025
Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Background: There are conflicting data on a potential association between atopic dermatitis (AD) and cardiovascular diseases (CVD). The aim of this study was to further explore this connection and whether there are biomarkers indicating the risk for CVD in AD patients.
Methods: We included 677 AD patients and 79 nonatopic controls from an observational multicenter case-control study (ProRaD: Prospective longitudinal study investigating the remission phase in patients with atopic dermatitis and other allergy-associated diseases).
Sci Rep
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2 pandemic. To enhance disease characterization and improve understanding of the underlying mechanisms, a comprehensive analysis of the plasma lipidome, metabolome and proteome was conducted in patients with viral and bacterial CAP infections, including those induced by SARS-CoV-2. Lipidomic, metabolomic and proteomic profiling were conducted on plasma samples of 69 patients suffering either from viral or bacterial CAP.
View Article and Find Full Text PDFBMJ Open
October 2024
Consellería de Sanidade e o Servizo Galego de Saúde, Santiago de Compostela, Spain.
Introduction: Linezolid is a broadly used antibiotic to treat complicated infections caused by gram-positive bacteria. Therapeutic drug monitoring of linezolid concentrations is recommended to maximise its efficacy and safety, mainly haematological toxicity. Different pharmacokinetic/pharmacodynamic targets have been proposed to improve linezolid exposure: the ratio of the area under the concentration-time curve during a 24-hour period to minimum inhibitory concentration (MIC) between 80 and 120; percentage of time that the drug concentration remains above the MIC during a dosing interval greater than 85% and the trough concentration between 2 and 7 mg/L.
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