Publications by authors named "Ann-Sophie Zielbauer"
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2 pandemic. To enhance disease characterization and improve understanding of the underlying mechanisms, a comprehensive analysis of the plasma lipidome, metabolome and proteome was conducted in patients with viral and bacterial CAP infections, including those induced by SARS-CoV-2. Lipidomic, metabolomic and proteomic profiling were conducted on plasma samples of 69 patients suffering either from viral or bacterial CAP.
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- The study investigates the serum levels of isoniazid and rifampicin in drug-sensitive TB patients treated between 2019 and 2023, focusing on sex-specific differences in drug levels.
- The research found that while there were no significant differences in isoniazid levels between sexes, female patients had higher rifampicin levels compared to male patients despite similar weight-adjusted dosing.
- Adverse effects were more prevalent in women during treatment, highlighting the need for clinicians to consider sex differences in therapeutic drug monitoring (TDM) for TB treatment.*
Article Synopsis
- Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is an increasing health issue, mainly caused by slow-growing mycobacteria (SGM) in Europe.
- A study analyzed 135 CT scans from 84 patients to investigate the correlation between clinical data and radiological features of various SGM species, especially emphasizing Mycobacterium avium complex.
- Findings suggest that patients with M. intracellulare had more severe CT results, and the study indicates that a specific CT scoring system could be beneficial for tracking disease progression and treatment decisions.
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- Tuberculosis (TB) is a significant global health issue, and severe cases can require ECMO therapy to manage life-threatening respiratory failure.
- A systematic review analyzed data from 43 TB patients treated with ECMO across 15 countries, revealing a high prevalence of ARDS and a strong survival rate of 81.4% post-treatment.
- The study suggests that ECMO is a viable option for TB patients experiencing acute respiratory or cardiac failure, emphasizing the importance of evaluating its effectiveness in future cases.
Introduction: Cesarean section (CS) rates are increasing worldwide. One constant indication is the breech presentation at term. By offering external cephalic version (ECV) and vaginal breech delivery CS rates can be further reduced.
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