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Measurement of renal volume is useful in the early detection and monitoring of renal disease. However, changes in renal volume during postural changes are not clear. Therefore, this study used multi-posture MRI system that can obtain renal images in any posture to assess the effect of posture on renal volume in the supine and upright positions. This study included 11 healthy volunteers (8 men and 3 women; mean age, 23.1 years; body mass index, 19.9 ± 1.3 kg/m). Multi-posture MRI was used to compare renal volumes (total kidney, renal cortex, renal medulla, and renal pelvis volumes) between supine and upright positions. Wilcoxon signed-rank test was used. A P < 0.05 indicated significance. The total kidney, renal cortex, and renal medulla volumes in the upright position were significantly smaller than those in the supine position (P < 0.05 for all). Multi-posture MRI may provide new information on renal volume.
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http://dx.doi.org/10.1007/s12194-025-00952-9 | DOI Listing |
Ren Fail
December 2025
Division of Nephrology, Department of Internal Medicine, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.
Peritoneal dialysis (PD) and hemodialysis (HD) are the two primary renal replacement therapies for patients with end-stage renal disease (ESRD). While PD is an effective and convenient modality, long-term use can lead to ultrafiltration failure, recurrent peritonitis, and progressive structural alterations in the peritoneal membrane, necessitating a transition to HD. In recent years, rather than a complete transition, the combined use of PD and HD has emerged as a viable alternative, offering potential advantages for selected patient populations.
View Article and Find Full Text PDFNMR Biomed
October 2025
Department of Radiology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Chronic kidney disease (CKD) is an increasing global health problem, resulting in gradual loss of renal function and irreversible renal injury. The noninvasive detection, monitoring, and timely intervention of CKD might benefit the patients' prognosis. This study aims to assess renal functional injury in CKD patients by using magnetic resonance imaging (MRI) of quantitative susceptibility mapping (QSM).
View Article and Find Full Text PDFInt J Antimicrob Agents
September 2025
Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, China; National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Fudan University, Shanghai, China. Electronic address:
Background: This study characterized the urinary pharmacokinetics and pharmacodynamics (PK/PD) of linezolid (LNZ) in critically ill patients with renal impairment and nosocomial multidrug-resistant Gram-positive urinary tract infections (UTIs). The aim was to address therapeutic challenges arising from limited treatment options and uncertain urinary excretion, to establish optimized dosing strategies.
Methods: A prospective observational study was conducted in ICU patients with renal impairment.
J Clin Virol
August 2025
Department of Microbiology, Singapore General Hospital, Singapore; SingHealth Duke-NUS Pathology Academic Clinical Programme, Singapore. Electronic address:
Background: Cytomegalovirus (CMV) is a major cause of morbidity and mortality for transplant and immunocompromised patients. While cell-mediated immunity (CMI) is crucial for control of CMV and can influence the management of patients, commercial kits to measure CMI responses have only recently become available. In this study, we evaluated 2 different test kit platforms to determine their performance with the aim of implementing CMV-CMI testing to serve local needs.
View Article and Find Full Text PDFRadiography (Lond)
September 2025
Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China; School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China; Jiangsu Provincial Engineering Research Center for Medical Imaging and Digital Medicine, Xuzhou, Jiangs
Introduction: Carotid artery disease is a major cause of stroke and is frequently evaluated using Carotid CT Angiography (CTA). However, the associated radiation exposure and contrast agent use raise concerns, particularly for high-risk patients. Recent advances in Deep Learning Image Reconstruction (DLIR) offer new potential to enhance image quality under low-dose conditions.
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