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Rhabdomyosarcoma (RMS) is an uncommon and aggressive malignancy originating from mesenchymal tissue, frequently affecting children. Its clinical presentation can vary significantly depending on the tumor's location and histological subtype, often complicating timely diagnosis. Early recognition and the initiation of appropriate multimodal treatment are essential to improving outcomes. This report describes a case of embryonal RMS (ERMS) in a young infant with a rapidly enlarging orbital mass and provides an overview of relevant diagnostic considerations and treatment strategies. The case highlights the value of early detection and coordinated, multidisciplinary care in achieving the best possible prognosis.
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http://dx.doi.org/10.7759/cureus.88028 | DOI Listing |
J Craniofac Surg
September 2025
Shenzhen Bao'an Clinical Medical College of Guangdong Medical University, Zhanjiang, China.
Scalp masses are common scalp lesions, most of which are benign, with a small proportion being malignant. Scalp sarcomas constitute one category of malignant tumors, primarily including fibrosarcoma, liposarcoma, rhabdomyosarcoma, and leiomyosarcoma. Among these, scalp leiomyosarcoma is exceedingly rare.
View Article and Find Full Text PDFJ Clin Ultrasound
September 2025
Division of Pediatric Surgery, Federico II University Hospital, Naples, Italy.
Paratesticular rhabdomyosarcoma (RMS) is a rare pediatric malignancy often misdiagnosed as benign conditions like epididymitis. We report a 4-year-old boy with paratesticular RMS and retroperitoneal metastasis, initially mistaken for epididymitis. The diagnostic delay resulted in disease progression, necessitating radical inguinal orchiectomy, hemiscrotectomy, and complete multimodal therapy.
View Article and Find Full Text PDFPediatr Dev Pathol
September 2025
The Hospital for Sick Children, Division of Pathology, Toronto, Canada.
Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. For stratification purposes, rhabdomyosarcoma is classified into fusion-positive RMS (alveolar rhabdomyosarcoma) and fusion-negative RMS (embryonal or spindle cell/sclerosing, FN-RMS) subtypes according to its fusion status. This study aims to highlight the pathologic and molecular characteristics of a cohort of FN-RMS using a targeted NGS RNA-Seq assay.
View Article and Find Full Text PDFAm J Case Rep
September 2025
Department of Otolaryngology - Head and Neck Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
BACKGROUND Pediatric sinonasal tumors are rare, accounting for about 4% of all pediatric head and neck neoplasms. Due to their nonspecific symptoms such as nasal obstruction, epistaxis, and facial pain, these tumors often present diagnostic challenges and lead to delays in managment. Early and accurate diagnosis is crucial to optimize clinical outcomes.
View Article and Find Full Text PDFSci Prog
September 2025
Department of Pathology, San Ai Tang Hospital, Lanzhou, China.
Although Müllerian adenosarcoma of the uterus shows weak malignant potential, there are still some factors indicating a worse prognosis. An incontinuous pelvic pain with urinary frequency, urgency, and hypouricemia arose in a mid-70s woman who refused to acknowledge the history of Tamoxifen use. A huge mass in the pelvis was found simultaneously by palpation, B-ultrasonography, and computed tomography.
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