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Auxetic structure has a very good application prospect in biomedical engineering as implant and stent design, but this scenario faces the difficulty of synergistic optimization of multiple performance indexes. This paper aims to break through this dilemma through innovative design concepts and methods. The study integrates bio-morphology and engineering biomimicry to design a chiral petal-type honeycomb structure by extracting the cross symmetry of cruciferous plant petals and the mechanical properties of wind turbine blades. The whole process framework of "bio-morphological feature extraction-parametric modeling -- multi-objective optimization -- application" is constructed. The neural network model is used to carry out multi-objective prediction, parameter sensitivity analysis, and structure optimization with the help of differential evolutionary algorithm. It is found that the designed structure greatly improves the adjustable range of negative Poisson's ratio, and at the same time, a smaller value of the chiral parameter la can make the structure improve the load carrying capacity in the elastic phase. Simulation of the balloon-expandable stent-vessel coupling process shows that the chiral petal-type cellular stent has outstanding advantages in reducing the stenosis rate maintaining the structural stability and dispersing the stress in the vessel wall among the three cellular structures. This study provides innovative technological solutions for medical device design, and is expected to promote the translation of metamaterial honeycomb structures from theoretical research to practical applications in the field of biomedical engineering, pointing out the direction of focusing on the optimization of key parameters and expanding the clinical applications for subsequent studies.
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http://dx.doi.org/10.1016/j.bioadv.2025.214453 | DOI Listing |
Genome Biol
September 2025
Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90089, USA.
Background: Recent advances in high-throughput sequencing technologies have enabled the collection and sharing of a massive amount of omics data, along with its associated metadata-descriptive information that contextualizes the data, including phenotypic traits and experimental design. Enhancing metadata availability is critical to ensure data reusability and reproducibility and to facilitate novel biomedical discoveries through effective data reuse. Yet, incomplete metadata accompanying public omics data may hinder reproducibility and reusability and limit secondary analyses.
View Article and Find Full Text PDFBiol Proced Online
September 2025
Division of Surface Physics, Department of Physics and Earth System Sciences, University of Leipzig, Linnéstr. 5, 04103, Leipzig, Germany.
Background: Organotypic long-term cultivation of vascularized retina explants is a major challenge for application in drug development, drug screening, diagnostics and future personalized medicine. With this background, an assay and protocol for organotypic culture of vascularized retina explants in vitro with optimum tissue integrity preservation is developed and demonstrated.
Methods: Morphological, histologic and biochemical integrity as well as viability of vascularized retina explants are compared as function of cultivation time for differently structured nanotube scaffolds.
Sci China Life Sci
September 2025
State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University Cancer Institute and Hospital, Tianjin Key Labora
Histone arginine methylation by protein arginine methyltransferases (PRMTs) is crucial for transcriptional regulation and is implicated in cancers. Despite their therapeutic potential, some PRMTs present challenges as drug targets due to their context-dependent activities. Here, we demonstrate that hypoxia triggers the rapid condensation of PRMT2, which is essential for its histone H3R8 asymmetric dimethylation (H3R8me2a) activity.
View Article and Find Full Text PDFEur Radiol Exp
September 2025
Center for MR-Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Background: Fetal MRI is increasingly used to investigate fetal lung pathologies, and super-resolution (SR) algorithms could be a powerful clinical tool for this assessment. Our goal was to investigate whether SR reconstructions result in an improved agreement in lung volume measurements determined by different raters, also known as inter-rater reliability.
Materials And Methods: In this single-center retrospective study, fetal lung volumes calculated from both SR reconstructions and the original images were analyzed.
Nat Aging
September 2025
Aging Biomarker Consortium (ABC), Beijing, China.
The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.
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