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Article Abstract
Diabetic wounds (DW) represent one of the most severe and persistent complications of diabetes, whose healing process is hindered by excessive accumulation of reactive oxygen species (ROS), dysregulated inflammation, and abnormal macrophage polarization. To address these multifactorial challenges, we developed an environment-responsive hydrogel (QF/SAB) using 2-formylphenylboronic acid (2-FPBA), salvianolic acid B (SAB), and quaternary chitosan (QCS) as raw materials, incorporating dynamic boronic ester and imine bonds. The QF/SAB hydrogel exhibited on-demand SAB release in response to hyperglycemia and oxidative stress, effectively scavenged excess ROS, inhibited bacterial growth, and promoted macrophage polarization towards the M2 phenotype. In vivo testing on a full-thickness diabetic wound model demonstrates that the QF/SAB hydrogel significantly accelerates healing by reducing inflammation, enhancing collagen deposition, and promoting angiogenesis, achieving 91.9 % healing by day 10, compared to 68.36 % in the control group. These characteristics position the QF/SAB hydrogel as a promising strategy for diabetic wound management.
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| http://dx.doi.org/10.1016/j.carbpol.2025.123995 | DOI Listing |
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