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Deep learning models rely heavily on extensive training data, but obtaining sufficient real-world data remains a major challenge in clinical fields. To address this, we explore methods for generating realistic synthetic multivariate fall data to supplement limited real-world samples collected from three fall-related datasets: SmartFallMM, UniMib, and K-Fall. We apply three conventional time-series augmentation techniques, a Diffusion-based generative AI method, and a novel approach that extracts fall segments from public video footage of older adults. A key innovation of our work is the exploration of two distinct approaches: video-based pose estimation to extract fall segments from public footage, and Diffusion models to generate synthetic fall signals. Both methods independently enable the creation of highly realistic and diverse synthetic data tailored to specific sensor placements. To our knowledge, these approaches and especially their application in fall detection represent rarely explored directions in this research area. To assess the quality of the synthetic data, we use quantitative metrics, including the Fréchet Inception Distance (FID), Discriminative Score, Predictive Score, Jensen-Shannon Divergence (JSD), and Kolmogorov-Smirnov (KS) test, and visually inspect temporal patterns for structural realism. We observe that Diffusion-based synthesis produces the most realistic and distributionally aligned fall data. To further evaluate the impact of synthetic data, we train a long short-term memory (LSTM) model offline and test it in real time using the SmartFall App. Incorporating Diffusion-based synthetic data improves the offline F1-score by 7-10% and boosts real-time fall detection performance by 24%, confirming its value in enhancing model robustness and applicability in real-world settings.
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http://dx.doi.org/10.3390/s25154639 | DOI Listing |
ACS Catal
August 2025
Department of Chemistry, University of Southern California, Los Angeles, California 90089, United States.
Chlorinated hydrocarbons are widely used as solvents and synthetic intermediates, but their chemical persistence can cause hazardous environmental accumulation. Haloalkane dehalogenase from (DhlA) is a bacterial enzyme that naturally converts toxic chloroalkanes into less harmful alcohols. Using a multiscale approach based on the empirical valence bond method, we investigate the catalytic mechanism of 1,2-dichloroethane dehalogenation within DhlA and its mutants.
View Article and Find Full Text PDFRSC Med Chem
August 2025
Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.
A strategy for targeting tumor-associated hypoxia utilizes reductase enzyme-mediated cleavage to convert biologically inert prodrugs to their corresponding biologically active parent therapeutic agents selectively in areas of pronounced hypoxia. Small-molecule inhibitors of tubulin polymerization represent unique therapeutic agents for this approach, with the most promising functioning as both antiproliferative agents (cytotoxins) and as vascular disrupting agents (VDAs). VDAs selectively and effectively disrupt tumor-associated microvessels, which are typically fragile and chaotic in nature.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Faculty of Fisheries, Recep Tayyip Erdogan University, Rize, Türkiye.
Application of anesthetic chemicals in aquaculture is important to minimize stress under normal operations such as handling, transport, and artificial breeding. In the past decade, the preference for natural anesthetics over synthetic ones has increased due to welfare issues regarding fish welfare and food safety. This study investigates the anesthetic efficacy of nutmeg oil () in three freshwater fish species- (Common carp), (Danube sturgeon), and (Rainbow trout)-by modeling behavioral (Induction and recovery times) and hematological responses using artificial neural networks (ANNs).
View Article and Find Full Text PDFFront Big Data
August 2025
MaiNLP, Center for Information and Language Processing, LMU Munich, Munich, Germany.
Predicting career trajectories is a complex yet impactful task, offering significant benefits for personalized career counseling, recruitment optimization, and workforce planning. However, effective career path prediction (CPP) modeling faces challenges including highly variable career trajectories, free-text resume data, and limited publicly available benchmark datasets. In this study, we present a comprehensive comparative evaluation of CPP models-linear projection, multilayer perceptron (MLP), LSTM, and large language models (LLMs)-across multiple input settings and two recently introduced public datasets.
View Article and Find Full Text PDFInquiry
September 2025
Rice University, Houston, TX, USA.
To evaluate changes in enrollment, average risk scores, and premiums in the Affordable Care Act individual market after states transitioned from the federally facilitated marketplace (Healthcare.gov) to a state-based marketplace (SBM) between 2018 and 2023. This study employed a retrospective, quasi-experimental design of secondary data using a synthetic difference-in-differences analysis methodology.
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