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: To evaluate the safety and efficacy of the simultaneous implantation of a monofocal capsular bag-fixated and a trifocal supplementary sulcus-fixated intraocular lens (duet procedure) in eyes with co-existing pathologies undergoing cataract or refractive lens surgery. : In total, 80 eyes of 40 consecutive patients, who underwent refractive lens exchange or cataract surgery and received the duet procedure due to minor co-pathologies, were included in this retrospective case series. Preoperative assessment comprised slit-lamp biomicroscopy, optical biometry, posterior-segment optical coherence tomography, corneal endothelial specular microscopy, corneal tomography, manifest refraction and distance and near visual acuity testing. Three months postoperatively, uncorrected distance (UDVA) and uncorrected near visual acuity (UNVA) were recorded. : The preoperative manifest refractive spherical equivalent (MRSE) was -0.31 ± 4.29 diopters (D), with a mean refractive astigmatism of -0.80 ± 0.60 D. At three months postoperatively, monocular UDVA and binocular UNVA significantly improved from 0.52 ± 0.42 logMAR and 0.32 ± 0.27 logMAR to 0.05 ± 0.09 logMAR and -0.03 ± 0.10 logMAR, respectively (both < 0.0001). : Reversible multifocality provided by the duet procedure appears to be a feasible option in eyes with mild co-existing pathologies, as it yields satisfactory visual and refractive outcomes with high safety.
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http://dx.doi.org/10.3390/jcm14155583 | DOI Listing |
J Biomol Struct Dyn
September 2025
Genomics and Human Genetics Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
Usher syndrome is an inherited condition that causes hearing and visual impairments, along with vestibular dysfunction, due to mutations in various genes, including , which codes for the scaffold protein SANS, essential for proper sensory function. This study employed a computational approach in order to analyze the potential impact of missense SNPs in . We started by curating and filtering SNPs from the Ensembl database, followed by a variety of computational prediction methods, such as SIFT, PolyPhen-2, MetaLR, BayesDel_addAF, and MutationTaster, to identify the pathogenic impact of the nsSNPs.
View Article and Find Full Text PDFBiomedicines
August 2025
enGenome S.R.L., 27100 Pavia, Italy.
Structural variants (SVs) play a significant role in gene function and are implicated in numerous human diseases. With advances in sequencing technologies, identifying SVs through whole-genome sequencing (WGS) has become a key area of research. However, variability in SV detection persists due to the wide range of available tools and the absence of standardized methodologies.
View Article and Find Full Text PDFJ Clin Med
August 2025
Department of Ophthalmology, LMU University Hospital, LMU Munich, 80336 Munich, Germany.
: To evaluate the safety and efficacy of the simultaneous implantation of a monofocal capsular bag-fixated and a trifocal supplementary sulcus-fixated intraocular lens (duet procedure) in eyes with co-existing pathologies undergoing cataract or refractive lens surgery. : In total, 80 eyes of 40 consecutive patients, who underwent refractive lens exchange or cataract surgery and received the duet procedure due to minor co-pathologies, were included in this retrospective case series. Preoperative assessment comprised slit-lamp biomicroscopy, optical biometry, posterior-segment optical coherence tomography, corneal endothelial specular microscopy, corneal tomography, manifest refraction and distance and near visual acuity testing.
View Article and Find Full Text PDFSci Adv
July 2025
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
A hybrid photoacoustic-fluorescence microscope films oxygen-carrying blood and spike-firing neurons across the mouse cortex in real time, revealing the hidden duet of neurovascular coupling.
View Article and Find Full Text PDFOphthalmologie
September 2025
Augenklinik, Goethe-Universität, Theodor-Stern-Kai 7, Frankfurt am Main, Deutschland.
Supplementary intraocular lenses (IOLs) are used to correct spherical and astigmatic refractive errors after cataract surgery. They provide patients with improved uncorrected visual acuity, resulting in a higher degree of spectacle independence. For the implantation of supplementary IOLs two approaches are distinguished: the primary and secondary Duet procedures.
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