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Article Abstract
A hybrid photoacoustic-fluorescence microscope films oxygen-carrying blood and spike-firing neurons across the mouse cortex in real time, revealing the hidden duet of neurovascular coupling.
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Usher syndrome is an inherited condition that causes hearing and visual impairments, along with vestibular dysfunction, due to mutations in various genes, including , which codes for the scaffold protein SANS, essential for proper sensory function. This study employed a computational approach in order to analyze the potential impact of missense SNPs in . We started by curating and filtering SNPs from the Ensembl database, followed by a variety of computational prediction methods, such as SIFT, PolyPhen-2, MetaLR, BayesDel_addAF, and MutationTaster, to identify the pathogenic impact of the nsSNPs.
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Center for Computer Research in Music and Acoustics, Department of Music, Stanford University, Stanford, CA, United States.
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