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Visual field (VF) testing remains a cornerstone in assessing retinal function by measuring how well different parts of the retina detect light. It is essential for early detection, monitoring, and management of many retinal diseases. By mapping retinal sensitivity, VF exams can reveal functional loss before structural changes become visible. This review summarizes how VF testing is applied across key conditions: hydroxychloroquine (HCQ) retinopathy, age-related macular degeneration (AMD), diabetic retinopathy (DR) and macular edema (DME), and inherited disorders including inherited dystrophies such as retinitis pigmentosa (RP). Traditional methods like the Goldmann kinetic perimetry and simple tools such as the Amsler grid help identify large or central VF defects. Automated perimetry (e.g., Humphrey Field Analyzer) provides detailed, quantitative data critical for detecting subtle paracentral scotomas in HCQ retinopathy and central vision loss in AMD. Frequency-doubling technology (FDT) reveals early neural deficits in DR before blood vessel changes appear. Microperimetry offers precise, localized sensitivity maps for macular diseases. Despite its value, VF testing faces challenges including patient fatigue, variability in responses, and interpretation of unreliable results. Recent advances in artificial intelligence, virtual reality perimetry, and home-based perimetry systems are improving test accuracy, accessibility, and patient engagement. Integrating VF exams with these emerging technologies promises more personalized care, earlier intervention, and better long-term outcomes for patients with retinal disease.
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http://dx.doi.org/10.3390/jcm14155266 | DOI Listing |
Cereb Cortex
August 2025
Nencki Institute of Experimental Biology, PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
In the visual cortices, receptive fields (RFs) are arranged in a gradient from small sizes in the center of the visual field to the largest sizes at the periphery. Using functional magnetic resonance imaging (fMRI) mapping of population RFs, we investigated RF adaptation in V1, V2, and V3 in patients after long-term photoreceptor degeneration affecting the central (Stargardt disease [STGD]) and peripheral (Retinitis Pigmentosa [RP]) regions of the retina. In controls, we temporarily limited the visual field to the central 10° to model peripheral loss.
View Article and Find Full Text PDFJ Glaucoma
September 2025
Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States.
Precis: Artificial intelligence applied to OCTA images demonstrated high accuracy in estimating 24-2 visual field maps by leveraging information from pararpapillary area.
Purpose: To develop deep learning (DL) models estimating 24-2 visual field (VF) maps from optical coherence tomography angiography (OCTA) optic nerve head (ONH) en face images.
Methods: A total of 3148 VF OCTA pairs were collected from 994 participants (1684 eyes).
J Glaucoma
September 2025
Department of Ophthalmology, Kurashiki Medical Center, Kurashiki, Okayama, Japan.
Prcis: Protocol 30-2 of Melbourne Rapid Fields, online computer perimetry, provides a portable, reliable, and patient-friendly alternative to Humphrey Field Analyzer 30-2 SITA fast protocol for Japanese all severity stages of glaucoma patients.
Purpose: Melbourne Rapid Fields (MRF) online computer perimetry is a web-browser-based software that offers white-on-white threshold perimetry using any computer. This study evaluates the perimetric results of 30-2 protocol from MRF performed using a laptop computer in comparison to Humphrey Field Analyzer (HFA).
J Vis
September 2025
Vrije Universiteit Amsterdam, Amsterdam Movement Sciences and Institute Brain and Behaviour Amsterdam (iBBA), Faculty of Behavioural and Movement Sciences, Amsterdam, Netherlands.
Eye tracking has the potential to be used as a meaningful measure of the consequences of vision impairment (VI), yet a comprehensive test battery is lacking. In this study, we sought to evaluate the feasibility and validity of a test battery of eye movements as a tool to measure visual performance in individuals with VI. A test battery including fixation stability, smooth pursuit, saccades, free viewing, and visual search was administered to 46 athletes with VI and 10 control participants.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Purpose: The purpose of this study was to investigate the focal relationship between choroidal thickness and retinal sensitivity in myopic eyes.
Methods: Participants underwent swept-source optical coherence tomography (SS-OCT) imaging and microperimetry testing. Choroidal thicknesses were obtained by segmenting the SS-OCT scans using a deep-learning approach.