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Healthcare Information Systems (HISs) are essential for improving care quality, managing chronic diseases, and supporting clinical decision-making. Despite significant investments, HIS implementations often fail due to the complexity of healthcare environments. Maturity Models (MMs) have emerged as tools to guide organizational improvement by assessing readiness, process efficiency, technology adoption, and interoperability. This study presents a comprehensive literature review identifying 45 Maturity Models used across various healthcare domains, including telemedicine, analytics, business intelligence, and electronic medical records. These models, often based on Capability Maturity Model Integration (CMMI), vary in structure, scope, and maturity stages. The findings demonstrate that structured maturity assessments help healthcare organizations plan, implement, and optimize HIS more effectively, leading to enhanced clinical and operational performance. This review contributes to an understanding of how different MMs can support healthcare digital transformation and provides a resource for selecting appropriate models based on specific organizational goals and technological contexts.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12346799 | PMC |
http://dx.doi.org/10.3390/healthcare13151847 | DOI Listing |
Alzheimers Dement
September 2025
Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Introduction: We compared and measured alignment between the Health Level Seven (HL7) Fast Healthcare Interoperability Resources (FHIR) standard used by electronic health records (EHRs), the Clinical Data Interchange Standards Consortium (CDISC) standards used by industry, and the Uniform Data Set (UDS) used by the Alzheimer's Disease Research Centers (ADRCs).
Methods: The ADRC UDS, consisting of 5959 data elements across eleven packets, was mapped to FHIR and CDISC standards by two independent mappers, with discrepancies adjudicated by experts.
Results: Forty-five percent of the 5959 UDS data elements mapped to the FHIR standard, indicating possible electronic obtainment from EHRs.
Front Immunol
September 2025
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34 hematopoietic stem cells without receiving prior bone marrow ablation or human secondary lymphoid tissue implantation, that still retains human mast cell- and basophil-dependent passive anaphylaxis responses. Its capacities for human antibody production and human B cell maturation, however, remain unknown.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University, Third Hospital, Beijing, China.
Objective: This study explores the metabolic profiles in the peripheral blood of infertile patients with adenomyosis (ADM) to identify key metabolites affecting pregnancy outcomes in these patients undergoing frozen embryo transfer (FET). Our goal is to create a metabolite-based clinical prediction model for pregnancy outcomes in adenomyosis-associated infertility.
Methods: This prospective cohort study from the Reproductive Center at Peking University Third Hospital enrolled 94 infertile patients with adenomyosis and control (CTRL) patients undergoing FET.
Drug Des Devel Ther
September 2025
Department of Neurosurgery, Peking University People's Hospital, Beijing, People's Republic of China.
Introduction: Parkinson's disease (PD) is a neurodegenerative disorder lacking therapies to replace lost dopaminergic neurons. Neural stem cell (NSC) transplantation faces survival and differentiation challenges. This study investigated feasibility and efficacy of paeoniflorin (PF) combined with NSC transplantation for PD treatment.
View Article and Find Full Text PDFFront Pharmacol
August 2025
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, China.
Diabetes mellitus is a metabolic disease with a high global prevalence, which affects blood vessels throughout the entire body. As the disease progresses, it often leads to complications, including diabetic retinopathy and nephropathy. Currently, in addition to traditional cellular and animal models, more and more organoid models have been used in the study of diabetes and have broad application prospects in the field of pharmacological research.
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