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Article Abstract
This study aimed to investigate the molecular epidemiology of carbapenem-resistant hypervirulent (CR-hvKP) ST23 in China. We conducted comprehensive searches across five databases (PubMed, Web of Science, MEDLINE, CNKI, and Wanfang) spanning 1980-2024, identifying 30 eligible studies through rigorous screening. Our synthesis documents 120 ST23 CR-hvKP clinical isolates, including the earliest known case from Zhejiang in 2013 which harbored alongside hallmark virulence loci (, , , , and ). Epidemiological analysis of 119 isolates reveals geographic disparities: Hebei (25.2%) and Jiangxi (22.7%) are hotspots, while carbapenemase distribution exhibits a north-south divide ( predominating in northern China versus in the south). Phylogenetic analysis of 584 global ST23 genomes suggests independent plasmid-mediated acquisition of carbapenemase genes, with evidence of clonal transmission both among humans and between humans and environmental niches. This review highlights the urgent need for surveillance to track CR-hvKP's evolving epidemiology, alongside interventions targeting plasmid-driven resistance spread.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351723 | PMC |
| http://dx.doi.org/10.1080/21505594.2025.2545556 | DOI Listing |
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