Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Altered gut microbiota has evidenced to be associated with colitis and colonic tumorigenesis, however bacteria-driven mechanism underlying inflammation-related colon pathologies remains undetermined. This study identifies a previously overlooked genus, Megasphaera, is highly abundant in inflammatory bowel diseases (IBD) and colorectal cancer (CRC) cohorts. A Megasphaera species, M. elsdenii reshapes colonic immunity by triggering dendritic cell (DC)-mediated Th1 and Th17 inflammation. Mechanistically, M. elsdenii and its lipopolysaccharide triggers DC activation via TLR4/NF-κB/IRF4 pathway. Accordingly, in Tlr4 mice, M. elsdenii colonization cannot expand colonic infiltration of DCs and fails to induce Th1 and Th17 responses in. In a Shanghai CRC cohort with a 100% detective rate for Megasphaera, the species of Megasphaera significantly dominated in early onset CRC patients (<50 years old) rather than late-onset CRC (≥50 years old). M. elsdenii and M. elsdenii-enriched microbiota exacerbate colonic inflammation and tumorigenesis in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced murine colitis-associated cancer model. Taken together, this study uncovers a pathogenic role of Megasphaera in developing colonic tumorigenesis via activating DC-mediated inflammation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/advs.202505670 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Burdock Tea Affects Pulmonary Microbiota and Physiology Through Short-Chain Fatty Acids in Wistar Rats.
Biology (Basel)
August 2025
College of Bioscience and Biotechnology, Yangzhou University, 48 East Wenhui Road, Yangzhou 225009, China.
The impact of burdock tea (BT) made from burdock () roots in normal individuals and animal models remains largely unknown, particularly on lung protection. This study examined responses of oxidative stress, inflammation, and the microbiota within the cecum and the lung to BT treatment in healthy Wistar rats. A middle-dose BT reduced the Chao1 and Shannon indices, and both low and middle doses induced structural alterations in the cecal microbiota.
View Article and Find Full Text PDFBacterial Vaginosis-Associated Prevotella timonensis Enhances Dendritic Cell-T Cell Clustering and Subsequent T Cell Proliferation.
Eur J Immunol
September 2025
Department of Experimental Immunology, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.
Dysbiosis of the vaginal microbiome is associated with increased inflammation in the female genital tract. Microbiota associated with bacterial vaginosis (BV), such as Gardnerella vaginalis, Megasphaera elsdenii, and Prevotella timonensis, replace the health-associated bacterium Lactobacillus crispatus and cause inflammation affecting mucosal integrity and immunity. However, it remains unclear how these BV-associated bacteria modulate immune cells and enhance inflammation.
View Article and Find Full Text PDFOral Microbiota Composition and Its Association with Gastrointestinal and Developmental Abnormalities in Children with Autism Spectrum Disorder.
Microorganisms
August 2025
Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, 60-830 Poznan, Poland.
Autism Spectrum Disorder (ASD) is frequently accompanied by gastrointestinal disturbances, dietary selectivity, and altered stress responses, with growing evidence pointing to gut-brain axis involvement. While intestinal microbiota has been extensively studied, the role of the oral microbiota remains underexplored. This study investigates the associations between oral microbiota composition and behavioral, gastrointestinal, dietary, and neuroendocrine parameters in children with ASD.
View Article and Find Full Text PDFEffects of simulated digestion on the α-glucosidase inhibitory activity, structure, and prebiotic activity of a polysaccharide from Bunge.
Front Nutr
August 2025
Heinz Mehlhorn Academician Workstation, Department of Nutrition and Food Hygiene, School of Public Health, Hainan Medical University, Haikou, Hainan, China.
This study explored the changes in the structure and α-glucosidase inhibitory activity of a non-starch polysaccharide derived from Bunge, AABP-1B, during digestion and its effect on host intestinal microbiota. Simulations of digestion in the upper digestive tract showed that the reducing sugar content and molecular weight of AABP-1B changed slightly, though no monosaccharides were detected. AABP-1B was resistant to degradation in the simulated upper gastrointestinal environments, retained strong α-glucosidase inhibitory activity after digestion, which may be related to the lack of structural changes.
View Article and Find Full Text PDFCharacteristics of gut and lung microbiota in patients with lung masses and their relationship with clinical features.
BMC Microbiol
August 2025
Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Objectives: The exploration of how dysbiosis relates to lung masses is still nascent, with few studies focusing on the microbial characteristics across various sites. Therefore, we categorized the microbiota into feces and bronchoalveolar fluid (BALF) groups to compare microbial characteristics between benign and malignant masses, analyze their clinical correlations, and develop predictive models for lung cancer.
Methods: A total of 238 fecal samples and 34 BALF samples were collected from patients with benign and malignant masses and then analyzed by 16 SrRNA.