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The intrinsic complexity of nonlinear optical phenomena offers a fundamentally new resource to analog brain-inspired computing, with the potential to address the pressing energy requirements of artificial intelligence. We introduce and investigate the concept of nonlinear inference capacity in optical neuromorphic computing in highly nonlinear fiber-based optical Extreme Learning Machines. We demonstrate that this capacity scales with nonlinearity to the point where it surpasses the performance of a deep neural network model with five hidden layers on a scalable nonlinear classification benchmark. By comparing normal and anomalous dispersion fibers under various operating conditions and against digital classifiers, we observe a direct correlation between the system's nonlinear dynamics and its classification performance. Our findings suggest that image recognition tasks, such as MNIST, are incomplete in showcasing deep computing capabilities in analog hardware. Our approach provides a framework for evaluating and comparing computational capabilities, particularly their ability to emulate deep networks, across different physical and digital platforms, paving the way for a more generalized set of benchmarks for unconventional, physics-inspired computing architectures.
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http://dx.doi.org/10.1515/nanoph-2025-0045 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Biology, Stanford University, Stanford, CA 94305.
Climate change is expected to pose significant threats to public health, particularly vector-borne diseases. Despite dramatic recent increases in dengue that many anecdotally connect with climate change, the effect of anthropogenic climate change on dengue remains poorly quantified. To assess this link, we assembled local-level data on dengue across 21 countries in Asia and the Americas.
View Article and Find Full Text PDFJ Appl Stat
January 2025
Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA.
The double-blinded randomized trial is considered the gold standard to estimate the average causal effect (ACE). The naive estimator without adjusting any covariate is consistent. However, incorporating the covariates that are strong predictors of the outcome could reduce the issue of unbalanced covariate distribution between the treated and controlled groups and can improve efficiency.
View Article and Find Full Text PDFNature
September 2025
Microsoft Research, Cambridge, UK.
Artificial intelligence (AI) and combinatorial optimization drive applications across science and industry, but their increasing energy demands challenge the sustainability of digital computing. Most unconventional computing systems target either AI or optimization workloads and rely on frequent, energy-intensive digital conversions, limiting efficiency. These systems also face application-hardware mismatches, whether handling memory-bottlenecked neural models, mapping real-world optimization problems or contending with inherent analog noise.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139.
Regulation of cell growth and division is essential to achieve cell-size homeostasis. Recent advances in imaging technologies, such as "mother machines" for bacteria or yeast, have allowed long-term tracking of cell-size dynamics across many generations, and thus have brought major insights into the mechanisms underlying cell-size control. However, understanding the governing rules of cell growth and division within a quantitative dynamical-systems framework remains a major challenge.
View Article and Find Full Text PDFEur J Gastroenterol Hepatol
July 2025
Department of Gastroenterology.
Background: Cardiovascular disease (CVD) risk increases in patients with metabolic-associated fatty liver disease (MAFLD). While sleep duration is linked to CVD risk, it is unclear whether it differs between individuals with and without MAFLD.
Methods: Data from the National Health and Nutrition Examination Survey (2007-2020; n = 10 386) were analyzed using multivariable logistic regression to examine the relationship between sleep duration and CVD.