Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Understanding the evolution and dynamics of deaths in people with HIV (PWH) is crucial to tailor interventions aiming at improving PWH long-term well-being. We aimed to assess all-cause and cause-specific mortality in PWH in Italy.
Methods: PWH enrolled before antiretroviral start from Icona cohort (78 Italian HIV clinics) between 1997 and 2021 (last observation December 2022) were included. Mortality was reported as incidence rate per 100 person-years of follow-up (PYFU). The mortality incidence rate according to calendar period was estimated by Poisson regression model.
Results: Overall, 17,006 PWH were included of whom 1584 (9.31%) died. The highest mortality rates were observed during the earliest calendar periods, with 2.67 (95% CI: 2.19-3.25) and 1.93 (95% CI: 1.67-2.22) deaths per 100 PYFU in 1997-1998 and 1999-2001, respectively. After 2010, mortality rates fell below 1 per 100 PYFU, reaching 0.74 (95% CI: 0.65-0.84) and 0.71 (95% CI: 0.63-0.80) in 2017-2019 and 2020-2022, respectively. A significant drop was observed for AIDS-related mortality in the first two periods from 1.45 (95% CI: 1.11-1.90) in 1997-1998 to 0.78 (95% CI: 0.62-0.97) deaths per 100 PYFU in 1999-2001. AIDS-related mortality continued to decrease in the subsequent years, with the lowest rate observed in the last two calendar periods: 0.10 (95% CI: 0.07-0.14) deaths per 100 person-years in 2017-2019 and 0.10 (95% CI: 0.08-0.15) deaths per 100 person-years in 2020-2022.
Conclusions: All-cause mortality in PWH in Italy significantly decreased over time, mainly for a reduction in AIDS-related mortality.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343120 | PMC |
| http://dx.doi.org/10.1093/ofid/ofaf455 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of diabetes on outcomes of patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease undergoing percutaneous coronary intervention.
Clin Res Cardiol
September 2025
Department of Cardiology, University Heart Center, University Hospital Zurich, Center for Translational and Experimental Cardiology (CTEC), University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Background: Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presenting with multivessel disease (MVD) and STEMI in a contemporary trial and the relevance of an immediate versus staged multivessel PCI strategy in this high-risk population.
Methods: Patients enrolled in the MULTISTARS AMI trial were stratified according to the presence/absence of diabetes.
Simulation Device for Uterine Atony in the Identification of Postpartum Hemorrhage: Overview of Prototyping, Testing, and Design Instructions.
Simul Healthc
September 2025
From the Pratt School of Engineering, Duke University, Durham, NC.
Introduction: Women who experience postpartum hemorrhage (PPH) after giving birth rapidly lose blood, which may lead to shock or death without immediate intervention. PPH most often results from uterine atony, when the uterus fails to contract after delivery. Worldwide, PPH causes 10 deaths hourly, with most deaths occurring in low-income settings.
View Article and Find Full Text PDFBurden of Disease Attributable to High Systolic Blood Pressure in Young Adults: An Analysis From the Global Burden of Disease Study 2021.
J Clin Hypertens (Greenwich)
September 2025
Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
This study aims to fill this gap by leveraging Global Burden of Disease 2021 (GBD 2021) data to conduct a comprehensive assessment of the disease burden attributable to high systolic blood pressure (SBP) in young adults. Data from the Global Health Data Exchange were utilized to estimate the disease burden attributable to high SBP in young adults, stratified by overall disease, sex, socio-demographic index (SDI) level, GBD region, nation, and specific disease. In 2021, the overall disease attributable to high SBP in young adults was substantial, with approximately 24,626,362 disability-adjusted life years (DALYs) and 477,992 deaths, and the DALYs and mortality rates were 623.
View Article and Find Full Text PDFJob control and working life expectancy in Sweden.
Scand J Work Environ Health
September 2025
Institution of Environmental Medicine, Karolinska Institutet. Solnavägen 4, 11365 Stockholm, Sweden.
Objectives: This study aimed to investigate the impact of low job control on labor market participation expressed through working life expectancy (WLE) and working years lost (WYL) among men and women in Sweden.
Methods: A random sample of 100 000 individuals was drawn from the Swedish Work, Illness, and labor market Participation (SWIP) cohort of the registered Swedish population in 2005 born 1945 to 1975. The multi-state estimated labor market affiliation method was used to estimate WLE and WYL due to unemployment, sickness absence, other, disability pension, early old-age pension, and death over a 15-year period (2006-2020).
BackgroundRAY1216 is an alpha-ketoamide-based peptide inhibitor of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) major protease (M). This study evaluated the absorption, distribution, metabolism and excretion of [C]-labelled RAY1216 by oral administration.Research design and methodsThis phase Ι study was designed to assess the pharmacokinetics, mass balance and metabolic pathways in 6 healthy Chinese adult men after a single fasting oral administration of 240 mL (containing 400 mg/100 μCi) [C] RAY1216.
View Article and Find Full Text PDF