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Speckle imaging through single multimode fibers (MMFs) has garnered significant attention for its minimally invasive nature and high imaging resolution. However, the prevalent fully serial sampling approach severely limits imaging speed. Here, we propose, to our knowledge, a novel method for achieving fast and high-resolution speckle imaging via optical coherence control. Employing highly coherent input light, high-quality single-speckle patterns are generated to ensure superior image fidelity. Simultaneously, utilizing the incoherence between different input lights, incoherent hybrid speckle patterns are generated, enabling parallel sampling and thereby enhancing imaging speed. This method not only accelerates imaging but also preserves high-quality results. The experimental results indicate that by using high-quality hybrid speckle pattern illumination, the sampling speed increases Q-fold, with Q being the number of single speckle patterns within each hybrid speckle pattern. Reconstructed images exhibit structural similarity indices of at least 0.75 and peak signal-to-noise ratios of at least 15.5 dB. Additionally, we verified that the hybrid speckle pattern illumination method is also applicable to perturbation rejection MMF imaging systems. Our proposed method offers, to our knowledge, a novel approach to enhancing the performance of MMF speckle imaging systems.
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http://dx.doi.org/10.1364/OE.546541 | DOI Listing |
IEEE Trans Med Imaging
September 2025
Intravoxel Incoherent Motion (IVIM) MRI is a contrast-agent-free microvascular imaging method finding increasing use in biomedicine. However, there is uncertainty in the ability of IVIM-MRI to quantify tissue microvasculature given MRI's limited spatial resolution (mm scale). Nine NRG mice were subcutaneously inoculated with human pancreatic cancer BxPC-3 cells transfected with DsRed, and MR-compatible plastic window chambers were surgically installed in the dorsal skinfold.
View Article and Find Full Text PDFKardiologiia
September 2025
Second Affiliated Hospital of Chongqing Medical University, Department of Ultrasound Medicine.
Objective This research investigated the application of real-time, three-dimensional speckle tracking imaging (RT-3D-STI) to evaluate left atrial (LA) function in individuals suffering from hypertensive heart disease (HHD) and heart failure with preserved ejection fraction (HFpEF).Material and methods This retrospective study included 100 patients with HHD and HFpEF hospitalized from August 2023to June 2024 (HFpEF group). 100 healthy individuals undergoing physical examinations comprised the control group.
View Article and Find Full Text PDFClin Interv Aging
September 2025
Department of Nephrology, Huadong Hospital, Fudan University, Shanghai, People's Republic of China.
Objective: This study evaluates cardiac function in older adults with T2DM and preserved LVEF using two-dimensional speckle-tracking echocardiography to explore the risk factors associated with subclinical left ventricular systolic dysfunction (GLS <18%) in this population.
Methods: All patients (n = 87, aged 60 years and above) and controls (n = 20) underwent clinical assessment and echocardiography, including GLS assessment.
Results: Univariate analysis identified gender (OR 3.
BMC Pediatr
September 2025
Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: This study aimed to evaluate the impact of asthma severity on biventricular cardiac functions using tissue Doppler imaging (TDI), two-dimensional speckle tracking echocardiography (2D-STE), and three-dimensional speckle tracking echocardiography (3D-STE).
Methods: Sixty-three children with asthma, aged between 5 and 16 years, were enrolled in the study along with 63 matched controls. All participants underwent cardiac assessments, including TDI, 2D-STE, 3D-STE, conventional echocardiography, and pulmonary function testing with spirometry.
JMIR Form Res
September 2025
Department of Critical Care Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangdong Provincial Geriatrics Institute, No. 106, Zhongshaner Rd, Guangzhou, 510080, China, 86 15920151904.
Background: Point-of-care ultrasonography has become a valuable tool for assessing diaphragmatic function in critically ill patients receiving invasive mechanical ventilation. However, conventional diaphragm ultrasound assessment remains highly operator-dependent and subjective. Previous research introduced automatic measurement of diaphragmatic excursion and velocity using 2D speckle-tracking technology.
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