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In interferenceless coded aperture correlation holography (I-COACH), it is still difficult to obtain high-quality edge-enhanced results due to the suppression of the modulation characteristics of the coded phase mask by cross-correlation operation. Here, we propose a deep learning-based edge-enhanced reconstruction method for I-COACH. Unlike the conventional method, which requires recording the point spread hologram of the system. Our proposed method, under the U-net architecture, directly establishes the mapping relationship between the object hologram of I-COACH and the edge-enhanced object. Thereby conveniently achieving high-quality edge-enhanced reconstruction compared with a complex iterative algorithm and a nonlinear edge enhancement algorithm. Moreover, the holograms obtained by different phase masks with different initial randomness and different occlusion interference are tested. When 90% of the pixels of the hologram are occluded, the network can still distinguish the feature of the object and achieve an acceptable edge-enhanced result, indicating strong robustness ability of the proposed method. Furthermore, the edge-enhanced imaging result of the 3D object at different depths demonstrates the applicability of the proposed network. Importantly, the proposed method provides a promising strategy of edge enhancement in 3D incoherent imaging and expands its application in pattern recognition and edge detection.
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http://dx.doi.org/10.1364/OE.557078 | DOI Listing |
Med Phys
September 2025
Department of Radiology, Stony Brook University, New York, USA.
Background: In contrast-enhanced digital mammography (CEDM) and contrast-enhanced digital breast tomosynthesis (CEDBT), low-energy (LE) and high-energy (HE) images are acquired after injection of iodine contrast agent. Weighted subtraction is then applied to generate dual-energy (DE) images, where normal breast tissues are suppressed, leaving iodinated objects enhanced. Currently, clinical systems employ a dual-shot (DS) method, where LE and HE images are acquired with two separate exposures.
View Article and Find Full Text PDFAdv Colloid Interface Sci
August 2025
Scientific and Didactic Laboratory of Nanotechnology and Material Technologies, Faculty of Mechanical Engineering, Silesian University of Technology, 44-100 Gliwice, Poland. Electronic address:
The rapid evolution of microelectronics requires materials that combine exceptional strength, ductility, and electrical conductivity for joining applications and durable lithium-ion battery anodes. Nanotwinned Cu (nt-Cu) surpasses conventional strengthening approaches, which often compromise ductility and conductivity, by using nanoscale twin boundaries to enhance both mechanical and electrical properties. This review examines the thermomechanical characteristics, fabrication methods, multiscale mechanistic insights, and technological applications of nt-Cu, bridging fundamental science with engineering practice.
View Article and Find Full Text PDFBiomaterials
August 2025
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address:
Wearable bioelectronics have transformed modern biomedical applications by enabling seamless integration with biological tissues, providing continuous, comprehensive, and personalized healthcare. Skin cancer, particularly melanoma, poses a significant clinical challenge due to its high metastatic potential and associated mortality. Traditional diagnostic approaches face limitations in accuracy, accessibility, and reproducibility, while existing treatments are often constrained by systemic toxicity and therapeutic resistance.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
School of Medicine, Chongqing University, Chongqing 400044, China.
Engineering functional exosomes represents a cutting-edge approach in biomedicine, holding the promise to transform targeted therapy. However, challenges such as achieving consistent modification and scalability have limited their wider adoption. Herein, we introduce a universal and effective strategy for engineering multifunctional exosomes through cell fusion.
View Article and Find Full Text PDFAppl Biochem Biotechnol
September 2025
School of Biological Sciences, University of the Punjab, Quaid-E-Azam Campus, P.O. 54590, Lahore, Pakistan.
Recombinant DNA technology is widely used to produce industrially and pharmaceutically important proteins. In silico analysis, performed before executing wet lab experiments has been greatly helpful in this connection. A shift in protein analysis has been observed over the past decade, driven by advancements in bioinformatics databases, tools, software, and web servers.
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