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In the medical field, Artificial Intelligence (AI) for diagnostic processes, particularly through deep learning techniques, has become increasingly advanced. Minor trauma, such as accidental cheek biting, sharp dental edges, or poorly fitting dentures, typically causes painful mouth ulcers and bump-like sores inside the mouth. Traditionally, diagnosing these ulcers involves a dentist or physician performing a physical examination, visually assessing the sores, and asking detailed questions about their size, location, duration, and related symptoms. Our research focuses on the advanced classification of oral ulcer stages using a convolutional neural network (CNN). To evaluate performance comprehensively, we developed and tested three custom models, comparing their effectiveness in distinguishing between different stages of oral ulcers. We also explored various optimizers and activation functions to determine the best configuration for improving model performance. Although our models show promising potential as diagnostic tools for oral ulcers, they occasionally make errors. Among the models tested, UlcerNet-2 stood out for its performance. Using the RMSprop optimizer along with Softmax and SELU activation functions, UlcerNet-2 achieved a validation accuracy of 96%. These results highlight UlcerNet-2's exceptional effectiveness in classifying oral ulcer stages, achieving a commendable balance of high accuracy, precision, and recall. This suggests UlcerNet-2 has significant potential as an advanced diagnostic tool, possibly enhancing clinical practices in detecting and staging oral ulcers. The proposed model (UlcerNet) was implemented on FogBus, the cloud framework to empirically evaluate the model performance in cloud-fog interoperable scenarios.
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http://dx.doi.org/10.1038/s41598-025-06951-5 | DOI Listing |
Lupus
September 2025
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
A 16-year boy had a history of rash, oral ulcers, alopecia, photosensitivity, cheilitis, and weight loss, for which he was started on steroids, methotrexate, and hydroxychloroquine from outside. Three years later, he developed pericardial effusion and peripheral neuropathy, that were managed at an outside hospital. Later, he presented to us with weight loss, diffuse rash, left facial palsy, and left lateral rectus palsy.
View Article and Find Full Text PDFTher Drug Monit
September 2025
Departments of Pharmacology, and.
Background: Fluconazole-tacrolimus interactions occur, but the additional effect of ritonavir is emphasized here, underscoring the need for careful prescription reconciliation in renal transplant recipients living with HIV-AIDS to prevent accidental ritonavir coadministration and inadvertent tacrolimus toxicity. The findings provide valuable insight for therapeutic drug monitoring (TDM) specialists. Patient informed consent was obtained for publication of the anonymized data.
View Article and Find Full Text PDFFront Dent Med
August 2025
Department of Otorhinolaryngology Head and Neck Surgery, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, China.
Background: With the increase in the resident population and the number of children in Ningbo, as well as the growing demand for oral health care, the number of children's dental emergencies has been increasing year by year. This trend not only increases the pressure on medical resources, but also puts higher demands on the level of children's oral emergency care. In order to better guide the diagnosis and treatment of common and frequent diseases in paediatric oral emergency care, and to improve the efficiency of the use of medical resources.
View Article and Find Full Text PDFFront Oral Health
August 2025
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Balance of the oral-intestinal axis microbiota is essential for maintaining oral mucosal health. The occurrence of oral disease is closely linked to the microbiota, this disorder is closely related to the pathogenesis of oral mucosal diseases, such as oral lichen planus, recurrent aphthous ulcer, oral candidiasis and squamous-cell carcinoma. As a microorganism that is beneficial to host health, probiotics can show multi-dimensional therapeutic effects in oral mucosal diseases by targeting and regulating the immune microenvironment of the oral mucosa, inhibiting the colonization of pathogenic bacteria and repairing the barrier function.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.
Famotidine (FMD) is an H₂-receptor antagonist with limited oral bioavailability and a short plasma half-life (2.5-4 h). Silk fibroin-chitosan nanoparticles (FBN-CS-NPs) represent a novel nanocarrier approach for treating peptic ulcers, combining biocompatibility, mucoadhesiveness, and pH-sensitive release.
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