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With the aim of improving efficiency and addressing limitations in paper-based clinical documentation, two resident doctors developed a customised electronic system for clinical note documentation on hospital wards. Using iterative co-design and active engagement with clinical colleagues, a ward moved from paper-based ward note-taking to electronic documentation. To demonstrate the benefits, the team conducted a comparative trial, assessing the in-house developed electronic patient record (EPR) system against the traditional paper notes in terms of efficiency and impact on working conditions. Following validation, the results were presented to, and endorsed by, the specialty Clinical Governance team. An implementation plan was subsequently formulated to introduce the EPR system across multiple hospital wards, utilising a stepwise approach. Various challenges emerged, leading to further iterative refinements to address issues encountered during each rollout phase. Challenges included raising hospital-wide awareness of participating wards, distributing training materials via channels compatible with real-world work patterns, overcoming hesitation about transition from paper-based systems, and addressing logistical hurdles with IT hardware deployment, which impaired the efficiency gains of the EPR system. Despite these challenges, the intervention demonstrated significant improvement in the timely handover of care at discharge from the hospital, with delays beyond 72 hours being eliminated.
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http://dx.doi.org/10.7759/cureus.87763 | DOI Listing |
J Hazard Mater
September 2025
State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China.
A novel vacuum ultraviolet (VUV)-activated sodium percarbonate (SPC) system (VUV/SPC) was developed for efficient degradation of micropollutants such as phenol. The VUV/SPC system achieved 98.4 % phenol removal within 3 min, with pseudo-first-order rate constants 4.
View Article and Find Full Text PDFJ Phys Chem B
September 2025
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan, ROC.
The synthesis of -tetrakis(3,4,5-trimethoxyphenyl)porphyrin [HT(3,4,5-OCH)PP] and cobalt(II) -tetrakis(3,4,5-trimethoxyphenyl)porphyrin [Co(T(3,4,5-OCH)PP)] has been successfully accomplished. The oxidation properties of [Co(T(3,4,5-OCH)PP)] have been assessed through UV-vis, NMR, and EPR techniques. It can be seen in the UV-vis spectrum that adding SbCl caused extra peaks to appear at 674 nm, which means that a π-cation radical was formed.
View Article and Find Full Text PDFBiomater Sci
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates.
Colorectal cancer (CRC) remains a major global health burden, necessitating more effective and selective therapeutic approaches. Nanocarrier-based drug delivery systems offer significant advantages by enhancing drug accumulation in tumors, reducing off-target toxicity, and overcoming resistance mechanisms. This review provides a comprehensive overview of recent advancements in nanocarriers for CRC therapy, including passive targeting the enhanced permeability and retention (EPR) effect, and active targeting strategies that exploit specific tumor markers using ligands such as antibodies, peptides, and aptamers.
View Article and Find Full Text PDFMar Pollut Bull
September 2025
CSIR-National Institute of Oceanography, Dona Paula, Goa, 403004, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
The Indian Sundarban Delta (ISD), located at the confluence of the Ganga-Brahmaputra-Meghna river system along India's eastern coast, is among the world's most geomorphologically dynamic and environmentally vulnerable deltaic systems. Over the past five decades, the region has undergone substantial morphodynamic changes driven by natural forces such as relative sea-level rise, wave action, and sediment flux, as well as anthropogenic factors like upstream water regulation via dams and barrages. This study examines the long-term evolution of shoreline and island morphology across the ISD from 1972 to 2025 using multi-temporal Landsat datasets under consistent tidal conditions.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
College of Smart Materials and Future Energy, Fudan University, Songhu Road 2005, Shanghai, 200438, P.R. China.
Solar-driven photocatalytic oxygen reduction reaction using covalent organic frameworks (COFs) offers a promising approach for sustainable hydrogen peroxide (HO) production. Despite their advantages, the reported COFs-based photocatalysts suffer insufficient photocatalytic HO efficiency due to the mismatched electron-proton dynamics. Herein, we report three one-dimensional (1D) COF photocatalysts for efficient HO production via the hydrogen radical (H•) mediated concerted electron-proton transfer (CEPT) process.
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