Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Chronic pain is a leading cause of disability, yet its underlying susceptibility traits remain unclear. Disorders like chronic pain may stem from extreme neural types, or archetypes, optimized for specific cognitive strategies and reflected in patterns of resting-state networks. Here, we examined a sample from the general population ( = 892) and three clinical samples with subacute back pain ( = 76), chronic back pain ( = 30), and treatment-resistant depression ( = 24). Using the sample from the general population, we found three neural archetypes that prioritize different cognitive strategies. Clinical pain samples, compared to the sample from the general population, mapped close to an archetype optimized for punishment learning (Archetype P). We replicated these results by recomputing the archetypes starting from the clinical pain samples, additionally revealing an association between Archetype P and pain severity. These findings suggest a neural-cognitive trait underlying susceptibility to chronic pain.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338593 | PMC |
| http://dx.doi.org/10.1101/2025.07.11.664303 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
More than pain: Speech, language, neurocognitive, and hearing issues among children with sickle cell disease.
J Natl Med Assoc
September 2025
Communication Equity Outcomes Laboratory, Department of Speech, Language and Hearing Sciences, University of Florida, Gainesville, FL, United States.
Importance: Significant advancements have been made in the management of sickle cell disease (SCD); an inherited blood disorder most prevalent among African Americans. While chronic pain is a hallmark of SCD and has been the primary focus of treatment, contemporary literature highlights the potential presence of developmental issues related to speech, language, neurocognitive, and auditory abilities that are often overlooked in SCD management.
Observations: This paper explores the spectrum of communication-related challenges that specifically affect children with SCD and fall within the scope of practice for speech-language pathologists (SLPs) and audiologists (AUDs).
Sex-specific genetics underlie increased chronic pain risk in women: decoding the genetic architecture of chronic pain. Comment on Br J Anaesth 2025; 135: 401-5.
Br J Anaesth
September 2025
Department of Anesthesiology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China; Department of Pain Management, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. Electronic address: 45285184@qq
Perceptions of Healthcare Professionals and Caregivers on the Use of Opioids: Cultural Aspects in a Rural Context in Uruguay.
Omega (Westport)
September 2025
Departamento de Bienestar y Salud, Universidad Católica del Uruguay, Uruguay.
A qualitative study using in-depth interviews was conducted to identify the level of knowledge, beliefs, and perceptions of family members and healthcare workers regarding the use of morphine as a pain treatment for individuals at the end of life. The study included healthcare professionals and caregivers of individuals who had died from serious illnesses affiliated with a rural health center in an inland city in the western region of Uruguay between August 2021 and June 2022. The findings may contribute to understanding the determinants that influence opioid use in healthcare centers lacking access to specialized palliative care.
View Article and Find Full Text PDFDisseminated Mycobacterium simiae infection causing rhinosinusitis in a severely immunocompromised patient.
Int J Infect Dis
September 2025
SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Microbiology and Biochemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontei
Background: Mycobacterium simiae is a slow-growing environmental nontuberculous mycobacterium (NTM), commonly isolated from soil and water. M. simiae is not known to transmit zoonotically or via human-to-human contact; infection is presumed to occur through direct environmental exposure.
View Article and Find Full Text PDFNeural basis of transcutaneous electrical nerve stimulation for neuropathic pain relief.
Neuron
September 2025
Shanghai Stomatological Hospital & School of Stomatology, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China. Electronic address:
Existing treatments for chronic pain often prove ineffective and carry adverse side effects, highlighting the need for better analgesics, including non-pharmacological treatments. We demonstrate that transcutaneous electrical nerve stimulation (TENS), when repeatedly applied during the early phase of nerve injury in mice, produces sustained analgesic effects by activating the dorsal column nucleus (DCN)-thalamic-cortical pathway, which transmits vibration, discriminative touch, and proprioception. Mechanistically, TENS selectively activates glutamatergic neurons in the DCN (DCN) via exciting Aβ low-threshold mechanoreceptors (Aβ-LTMRs) in dorsal root ganglia (DRGs).
View Article and Find Full Text PDF